Tuberous sclerosis complex is caused by mutations in tumor suppressor genes TSC1 or TSC2 and is characterized by the pre...
...TSC2. Cells undergo bi-allelic inactivation of either gene to give rise to tumors in a classic tumor suppressor "two-hit...
...TSC2, which encode hamartin and tuberin, respectively. Tuberin and hamartin form a complex that inhibits signaling by th...
...tsc2, mapped to the distal tip of the short arm of chromosome 2B. This gene was responsible for the effects of a major Q...
...TSC2). Here we evaluate this model genetically in Drosophila by engineering Tsc2 mutants in which the Akt phosphorylatio...
...TSC2 in PTEN(+/+) cells attenuated the size arrest. Radiation treatment potentiated Akt activation in PTEN(-/-) but not ...
...TSC2 gene mutations in TSC lead to mTOR pathway activation and p70S6kinase (phospho-S6K) and ribosomal S6 (phospho-S6) p...
...TSC2/tuberin, acts as a negative regulator of mTOR/S6K1 signalling. Mutations in either TSC1 or TSC2 are genetically lin...
...TSC2). Diagnosis is established with the identification of various neurocutaneous markers and multiple organ system hama...
...TSC2, can be mutated, resulting in the tuberous sclerosis complex phenotype. The protein products of the tuberous sclero...
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