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Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70.

Vu(C B),Corpuz(E G),Merry(T J),Pradeepan(S G… J Med Chem 1999-11-04

...Syk, as well as other SH2-containing proteins such as Src and Grb2. Gel shift studies using a protein construct consisti...

Ligand binding specificities and signal transduction pathways of Fc gamma recep…

Metes(D),Manciulea(M),Pretrusca(D),Rabinowic… Eur J Immunol 1999-10-26

...Syk protein tyrosine kinases, although the CD3 zeta chain was not found to functionally associate with FcgammaRIIc1. In ...

Requirement of a Src family kinase for initiating calcium release at fertilizat…

Giusti(A F),Carroll(D J),Abassi(Y A),Terasak… J Biol Chem 1999-11-09

...Syk, and ZAP-70), and the SH3 domain of Src, were not inhibitory. Also, a point-mutated Src SH2 domain, which has reduce...

Involvement of receptor aggregation and reactive oxygen species in osmotic stre…

Qin(S),Ding(J),Takano(T),Yamamura(H) Biochem Biophys Res Commun 1999-09-23

...Syk activation. Osmotic stress-induced Syk activation depended partly upon aggregation of surface receptors. Moreover, i...

SLAP, a dimeric adapter protein, plays a functional role in T cell receptor sig…

Tang(J),Sawasdikosol(S),Chang(J H),Burakoff(… Proc Natl Acad Sci U S A 1999-09-09

...Syk, LAT, and TCRzeta chain in Jurkat T cells. In transiently transfected COS-7 cells, SLAP forms separate complexes wit...

Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts wit…

Veale(M),Raab(M),Li(Z),da Silva(A J),Kraeft(… J Biol Chem 1999-11-02

...SYK as well as lymphoid proteins such as SLP-76 and FYB/SLAP. FYB/SLAP has the hallmarks of an adaptor protein that bind...

CR3, FcgammaRIIA and FcgammaRIIIB induce activation of the respiratory burst in…

Löfgren(R),Serrander(L),Forsberg(M),Wilsson(… Biochim Biophys Acta 1999-11-23

...syk) whereas FcgammaRIIIB induced only a very weak p72(syk) phosphorylation. During CR3 stimulation no tyrosine phosphor...

Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec …

Ohya(K),Kajigaya(S),Kitanaka(A),Yoshida(K),M… Proc Natl Acad Sci U S A 1999-11-24

...Syk, or c-Abl, induced marked phosphorylation of BRDG1 on tyrosine residues. BRDG1 was also phosphorylated by Tec direct...

Src-regulated extracellular signal-related kinase and Syk-regulated c-Jun N-ter…

Cambien(B),Millet(M A),Schmid-Antomarchi(H),… J Immunol 1999-11-19

...Syk. Each kind of the nonreceptor tyrosine kinase blockers efficiently inhibits the vincristine-induced IL-1 production ...

Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-media…

Craxton(A),Jiang(A),Kurosaki(T),Clark(E A) J Biol Chem 1999-11-23

...Syk- and Btk-deficient DT40 cells and B cells from Lyn(-/-) mice. BCR-mediated Akt activation required Syk and was parti...

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