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The engagement of beta1 integrins on promonocytic cells promotes phosphorylatio…

Miller(L A),Hong(J J),Kinch(M S),Harrison(M … Eur J Immunol 1999-06-30

The protein-tyrosine kinase Syk participates in signal transduction pathways downstream from multiple immune recognition...

Analysis of tyrosine phosphorylation-dependent interactions between stimulatory…

Yohannan(J),Wienands(J),Coggeshall(K M),Just… J Biol Chem 1999-07-15

...Syk. The results obtained indicate that the protein tyrosine kinase Syk interacts with multiple CD22-derived phosphopept...

Genetic analysis of B cell antigen receptor signaling.

Kurosaki(T) Annu Rev Immunol 1999-08-31

...Syk, Btk) in BCR signaling and B cell development. Combinations of intracellular signaling pathways downstream of these ...

SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast …

Pivniouk(V I),Martin(T R),Lu-Kuo(J M),Katz(H… J Clin Invest 1999-07-07

SLP-76 is an adapter protein expressed in T cells and myeloid cells that is a substrate for ZAP-70 and Syk. SLP-76-defic...

Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role fo…

Lupher(M L),Rao(N),Lill(N L),Andoniou(C E),M… J Biol Chem 1999-02-03

...Syk Tyr323 in the negative regulation of Syk. Co-expression of Cbl with Syk in COS-7 cells led to a dose-dependent decre...

Induction of the antigen receptor expression on B lymphocytes results in rapid …

Zhang(Y),Wienands(J),Zürn(C),Reth(M) EMBO J 1999-02-16

...Syk, and the phosphorylation of several substrate proteins including HS1 and SLP-65. How these signaling elements are co...

Compounds capable of generating singlet oxygen represent a source of artifactua…

Pai(J J),Kirkup(M P),Frank(E A),Pachter(J A)… Anal Biochem 1999-07-21

...Syk. An assay artifact is reported here as a caveat to others. The SPA used an antibody to couple glutathione-S-transfer...

Characterization of anergic anti-DNA B cells: B cell anergy is a T cell-indepen…

Noorchashm(H),Bui(A),Li(H L),Eaton(A),Mandik… Int Immunol 1999-06-23

...Syk, upon mIg stimulation. Importantly, anti-DNA B cell anergy is maintained in the absence of T cells since both anti-s...

T cell antigen-receptor signal transduction.

van Leeuwen(J E),Samelson(L E) Curr Opin Immunol 1999-08-20

...Syk family. Studies on LAT, SLP-76, Itk and Vav have revealed their role in the activation of Ras and phospholipase-Cgam...

Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-in…

Sudbeck(E A),Liu(X P),Narla(R K),Mahajan(S),… Clin Cancer Res 1999-09-30

...SYK family tyrosine kinase SYK, the TEC family tyrosine kinase BTK, the SRC family tyrosine kinase LYN, or the receptor ...

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