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Ligand binding specificities and signal transduction pathways of Fc gamma recep…

Metes(D),Manciulea(M),Pretrusca(D),Rabinowic… Eur J Immunol 1999-10-26

...Syk protein tyrosine kinases, although the CD3 zeta chain was not found to functionally associate with FcgammaRIIc1. In ...

Role of Syk in Fc gamma receptor-coupled tyrosine phosphorylation of Cbl in a m…

Hazeki(K),Hazeki(O),Matsuo(T),Seya(T),Yamash… Eur J Immunol 1999-11-16

...Syk by prior immunoprecipitation with anti-Syk antibodies. Exposure of the (32)P-labeled cells to PMA resulted in phosph...

G(s)alpha repression of adipogenesis via Syk.

Wang(H y),Malbon(C C) J Biol Chem 1999-12-13

...Syk-specific antibodies demonstrated the presence of Syk in fibroblasts and a rapid increase in the amount of phospho-Sy...

Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70.

Vu(C B),Corpuz(E G),Merry(T J),Pradeepan(S G… J Med Chem 1999-11-04

...Syk, as well as other SH2-containing proteins such as Src and Grb2. Gel shift studies using a protein construct consisti...

Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec …

Ohya(K),Kajigaya(S),Kitanaka(A),Yoshida(K),M… Proc Natl Acad Sci U S A 1999-11-24

...Syk, or c-Abl, induced marked phosphorylation of BRDG1 on tyrosine residues. BRDG1 was also phosphorylated by Tec direct...

Reactive oxygen intermediates enhance Fc gamma receptor signaling and amplify p…

Pricop(L),Gokhale(J),Redecha(P),Ng(S C),Salm… J Immunol 1999-06-30

...Syk, a tyrosine kinase required for phagocytic function, in a catalase-sensitive manner. Our results provide a mechanism...

CD94/NKG2-A inhibitory complex blocks CD16-triggered Syk and extracellular regu…

Palmieri(G),Tullio(V),Zingoni(A),Piccoli(M),… J Immunol 1999-06-30

...Syk kinase together with tyrosine phosphorylation of CD16 receptor zeta subunit are markedly inhibited by the coengageme...

Genetic analysis of B cell antigen receptor signaling.

Kurosaki(T) Annu Rev Immunol 1999-08-31

...Syk, Btk) in BCR signaling and B cell development. Combinations of intracellular signaling pathways downstream of these ...

Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-in…

Sudbeck(E A),Liu(X P),Narla(R K),Mahajan(S),… Clin Cancer Res 1999-09-30

...SYK family tyrosine kinase SYK, the TEC family tyrosine kinase BTK, the SRC family tyrosine kinase LYN, or the receptor ...

The role of actin microfilaments in the down-regulation of the degranulation re…

Frigeri(L),Apgar(J R) J Immunol 1999-04-13

...Syk and increased tyrosine phosphorylation of the receptor itself by the tyrosine kinase Lyn. This indicates that the ve...

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