...Tsc2 allele while retaining two copies of chromosome 10 containing the mutant Tsc2 allele along with two normal copies o...
...TSC2 region of chromosome 16p13 from patients with LAM. We found that angiomyolipomas contain five morphologically disti...
...TSC2, is characterized by the development of hamartomas in a variety of organs. The proteins encoded by TSC1 and TSC2, h...
...TSC2 gene, at chromosome 9q34 and 16p13.3. Inactivation of both alleles at TSC1 or TSC2 loci is associated with the deve...
...TSC2, in which progression to malignancy is rare. Primary Tsc2(-/-) murine embryo fibroblast cultures display early sene...
Mutation in either TSC1 or TSC2 causes the autosomal dominant disorder tuberous sclerosis, in which widespread hamartoma...
...TSC2 on chromosome 16p13.3, encoding tuberin. Although several different functions of these proteins have been described...
...TSC2). Two-thirds of the cases are sporadic and result from new mutations. The aim of this study was to determine TSC2 g...
Mutations that inactivate either TSC1 or TSC2 cause tuberous sclerosis. We have used immunoblotting and immunohistochemi...
...Tsc2 in the TOR (target of rapamycin) signalling pathway to control growth, and that a major effector of Rheb function i...
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