...Tsc2 renders cells resistant to amino acid starvation. We propose that the Tsc1-Tsc2 complex antagonizes the TOR-mediate...
...TSC2 tumor suppressor genes, are closely related to their direct interactions. However, the regulation of the hamartin-t...
...TSC2 genes give rise to the clinical disorder of tuberous sclerosis characterized by the development of hamartomas predo...
...TSC2 have been isolated, the molecular pathogenesis of the disease is not understood. We examined cell cycle abnormaliti...
...TSC2 gene, which has been implicated in the pathogenesis of tuberous sclerosis complex. Here, we describe the clinical a...
...TSC2 genes lead to clear cell renal carcinogenesis via an alternate pathway not involving VHL mutations.
...TSC2 and its protein product tuberin promotes the development of benign lesions by stimulating cell growth, although the...
...TSC2. 75% of cases are sporadic. Most patients with TS have epilepsy. Infantile spasms are a frequent early manifestatio...
...TSC2 mutations. Patients were genotyped for an interferon-gamma (IFN-gamma) microsatellite polymorphism, within intron 1...
...TSC2 genes. While the development of seizures is ultimately related to mutations in one of the two genes, the mechanism ...
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