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Structural requirements of Syk kinase for Fcgamma receptor-mediated phagocytosi…

Hunter(S),Sato(N),Kim(M K),Huang(Z Y),Chu(D … Exp Hematol 1999-06-07

...Syk's effect on phagocytosis. Furthermore, the Syk variant SykB, lacking 23 amino acids in the unique region, signaled f...

Cutting edge: extracellular signal-regulated kinase activates syk: a new potent…

Xu(R),Seger(R),Pecht(I) J Immunol 1999-08-12

...Syk is an essential element in several cascades coupling Ag receptors to cell responses. Syk and the mitogen-activated p...

Cell volume-dependent regulation of L-selectin shedding in neutrophils. A role …

Rizoli(S B),Rotstein(O D),Kapus(A) J Biol Chem 1999-08-19

...Syk, and Pyk2, but prevention of their activation by the Src-family inhibitor PP1 failed to affect the L-selectin respon...

Compartmentalized IgE receptor-mediated signal transduction in living cells.

Stauffer(T P),Meyer(T) J Cell Biol 1998-01-13

...Syk SH2 domains selectively bind to Syk and IgE receptors, respectively. Unlike the predicted prelocalization of EGF rec...

Functional role for Syk tyrosine kinase in natural killer cell-mediated natural…

Brumbaugh(K M),Binstadt(B A),Billadeau(D D),… J Exp Med 1998-01-13

...Syk in natural cytotoxicity. Biochemical analyses indicate that Syk is tyrosine phosphorylated after stimulation with a ...

Syk tyrosine kinase is required for the positive selection of immature B cells …

Turner(M),Gulbranson-Judge(A),Quinn(M E),Wal… J Exp Med 1998-01-13

...Syk in the B cells themselves. Syk-deficient B cells are shown to have the life span of normal immature B cells. If this...

Interleukin-3 activates Syk in a human myeloblastic leukemia cell line, AML193.

Tsubokawa(M),Tohyama(Y),Tohyama(K),Asahi(M),… Eur J Biochem 1998-01-15

...Syk with IL-3-mediated signaling and found that the IL-3 receptor beta subunit was immunoprecipitated with Syk. Since th...

Tandem SH2 domains confer high specificity in tyrosine kinase signaling.

Ottinger(E A),Botfield(M C),Shoelson(S E) J Biol Chem 1998-02-09

...Syk, SHP-2, and phospholipase C-gamma1. Bisphosphorylated TAMs (tyrosine-based activation motifs) were derived from biol...

Activation of protein-tyrosine kinase Pyk2 is downstream of Syk in FcepsilonRI …

Okazaki(H),Zhang(J),Hamawy(M M),Siraganian(R… J Biol Chem 1998-01-22

...Syk. In contrast, tyrosine phosphorylation of Pyk2 by stimulation of G-protein-coupled receptors was independent of Syk....

Proteolytic cleavage of the beta1 subunit of platelet alpha2beta1 integrin by t…

Kamiguti(A S),Markland(F S),Zhou(Q),Laing(G … J Biol Chem 1998-01-22

...syk) and phospholipase Cgamma2. These events are dependent on the main platelet collagen receptor, alpha2beta1 integrin ...

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