...TSC2 rescues the migration phenotype of myr-Akt1-expressing tumor cells, and high levels of TSC2 in breast cancer patien...
...TSC2 on chromosome 16p13.3 encoding tuberin. TSC patients carry a mutant TSC1 or TSC2 gene in each of their somatic cell...
...TSC2 genes are making genotype-phenotype correlations possible. While managing seizures, cognitive dysfunction, and beha...
...TSC2 genes. The disorder typically has profound neurologic involvement and often presents early in life with epilepsy, d...
...TSC2 possess high levels of Rheb-GTP resulting in constitutive mTOR activation. We have shown previously that the TSC1/T...
TSC1, encoding hamartin, and TSC2, encoding tuberin, are tumor suppressor genes responsible for the autosomal dominantly...
...Tsc2 gene mutant), which is a homolog of the human mesothelin/megakaryocyte potentiating factor gene, and a novel ELISA ...
...TSC2. In these settings, GSK3 phosphorylation is sensitive to mTORC1 inhibition by rapamycin or amino acid withdrawal, a...
...TSC2 (tuberin). The LKB1-->AMPK-->TSC2 pathway negatively regulates the target of rapamycin (TOR), and this appears to b...
...TSC2 gene, although autism can and does develop in children with TSC1 mutations. The likelihood is also greater if the c...
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