The tuberous sclerosis tumor suppressors TSC1 and TSC2 regulate the mTOR pathway to control translation and cell growth ...
...Tsc2 mutant Long-Evans rats.
...TSC2 promoter. In breast tissues, however, a very small number of samples were found to have methylation of the TSC2 pro...
...Tsc2 loss of heterozygosity (LOH) in both Tsc2+/- and Pten+/-Tsc2+/- mice. These findings demonstrate that inactivation ...
The PTEN and TSC2 tumor suppressors inhibit mammalian target of rapamycin (mTOR) signaling and are defective in distinct...
...TSC2, and a number of proto-oncogenes including PI3K, Akt, and eIF4E, and mTOR signaling is constitutively activated in ...
...TSC2 genes.,A mutation (R611Q) was found in exon 16 of the TSC2 gene. Thus far, neither clinically unaffected parents ha...
...TSC2), which is a negative regulator of mTOR. Here we establish an additional pathway by which Akt inhibits TSC2 and act...
...TSC2 complex through FIP200 binding to TSC1. We found that association of FIP200 with the TSC1-TSC2 complex correlated w...
...TSC2 complex, both of which respond to energy deprivation in cells. In addition, glucose starvation not only signals to ...
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