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T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70.

Zeitlmann(L),Knorr(T),Knoll(M),Romeo(C),Siri… J Biol Chem 1998-07-09

...Syk, in which conserved C-terminal tyrosine residues have been replaced by phenylalanines (ZAP YF-C, Syk YF-C). Both mut...

Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk familie…

Cao(M Y),Huber(M),Beauchemin(N),Famiglietti(… J Biol Chem 1998-07-09

...Syk, Itk, and Pyk2. Using site-directed mutagenesis and peptide phosphorylation studies, we found that these PTKs were e...

Major histocompatibility class II-mediated signal transduction is regulated by …

Greer(S F),Lin(J),Clarke(C H),Justement(L B) J Biol Chem 1998-06-05

...Syk and phospholipase Cgamma, and the production of inositol 1,4,5-trisphosphate leading to intracellular mobilization a...

Evidence for involvement of two isoforms of Syk protein-tyrosine kinase in sign…

Yamashita(T),Kairiyama(L),Araki(M),Nagasawa(… J Biochem 1998-08-17

...Syk can mediate signal transduction in mast cells and suggest that the 23-amino acid insert in the linker region of Syk ...

A unique insert in the linker domain of Syk is necessary for its function in im…

Latour(S),Zhang(J),Siraganian(R P),Veillette… EMBO J 1998-06-18

...Syk, termed SykB, which lacks a 23 amino acid sequence in the linker domain. As this 'linker insert' is also not present...

An improved retroviral gene transfer technique demonstrates inhibition of CD4-C…

Sugawara(T),Di Bartolo(V),Miyazaki(T),Nakauc… J Immunol 1998-10-06

ZAP-70 is a Syk family tyrosine kinase that plays an essential role in initiating TCR signals. Deficiency in ZAP-70 caus...

Chimeric receptors composed of phosphoinositide 3-kinase domains and FCgamma re…

Lowry(M B),Duchemin(A M),Coggeshall(K M),Rob… J Biol Chem 1998-10-15

...Syk/ZAP 70 family kinases, and phosphoinositide 3-kinase (PI3-K). To test directly the role of PI3-K in mediating phagoc...

Tyrosine 112 of latent membrane protein 2A is essential for protein tyrosine ki…

Fruehling(S),Swart(R),Dolwick(K M),Kremmer(E… J Virol 1998-10-07

...Syk protein tyrosine kinase (PTK) with LMP2A occurs at the two tyrosines of the LMP2A immunoreceptor tyrosine-based acti...

Syk tyrosine kinase and B cell antigen receptor (BCR) immunoglobulin-alpha subu…

Lankar(D),Briken(V),Adler(K),Weiser(P),Cassa… J Exp Med 1998-09-24

...syk mutants. Thus, we found that the syk tyrosine kinase, an effector of the BCR signal transduction pathway, is involve...

Phosphorylation of the Grb2- and phosphatidylinositol 3-kinase p85-binding p36/…

von Willebrand(M),Williams(S),Tailor(P),Must… Cell Signal 1998-10-28

...Syk dependent, and it was seen only upon triggering of the TCR complex. Thus, p36/38 was phosphorylated by Syk or a Syk-...

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