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Positive versus negative signaling by lymphocyte antigen receptors.

Healy(J I),Goodnow(C C) Annu Rev Immunol 1998-08-05

...syk), tyrosine or lipid phosphatases (CD45, SHP-1, SHIP), and accessory molecules (CD21/CD19, CD22, FcR gamma 2b). Under...

Evidence for involvement of two isoforms of Syk protein-tyrosine kinase in sign…

Yamashita(T),Kairiyama(L),Araki(M),Nagasawa(… J Biochem 1998-08-17

...Syk can mediate signal transduction in mast cells and suggest that the 23-amino acid insert in the linker region of Syk ...

T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70.

Zeitlmann(L),Knorr(T),Knoll(M),Romeo(C),Siri… J Biol Chem 1998-07-09

...Syk, in which conserved C-terminal tyrosine residues have been replaced by phenylalanines (ZAP YF-C, Syk YF-C). Both mut...

Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk familie…

Cao(M Y),Huber(M),Beauchemin(N),Famiglietti(… J Biol Chem 1998-07-09

...Syk, Itk, and Pyk2. Using site-directed mutagenesis and peptide phosphorylation studies, we found that these PTKs were e...

Syk activation is required for spreading and H2O2 release in adherent human neu…

Fernandez(R),Suchard(S J) J Immunol 1998-05-28

...Syk-selective inhibitor, blocked Syk activity, cell spreading, and H2O2 release, indicating that Syk activity was requir...

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-…

Fluckiger(A C),Li(Z),Kato(R M),Wahl(M I),Och… EMBO J 1998-06-01

...Syk dramatically reduced the initial phase calcium response, demonstrating that Btk/Tec and Syk family kinases may exert...

The protein tyrosine kinases of the sea urchin Anthocidaris crassispina.

Sakuma(M),Onodera(H),Suyemitsu(T),Yamasu(K) Zoolog Sci 1998-04-14

...Syk/ZAP70 family. NRTK5 is the Csk-type kinase of the sea urchin, which is known to negatively regulate the Src family k...

Alterations in human B cell calcium homeostasis by polycyclic aromatic hydrocar…

Mounho(B J),Burchiel(S W) Toxicol Appl Pharmacol 1998-04-16

...Syk. Inhibition of tyrosine phosphorylation by herbimycin A was found to largely prevent the increase in intracellular C...

Asymmetrical phosphorylation and function of immunoreceptor tyrosine-based acti…

Pao(L I),Famiglietti(S J),Cambier(J C) J Immunol 1998-04-21

...Syk phosphorylation. However CD79a-ITAM and CD79b-ITAM tyrosine phosphorylations were asymmetrical, with >80% of phospho...

Activation of lyn, blk, and btk but not syk in CD72-stimulated B lymphocytes.

Venkataraman(C),Muthusamy(N),Muthukkumar(S),… J Immunol 1998-04-21

...syk was not activated in CD72-stimulated cells whereas the tec family kinase btk was activated in both CD72- and BCR-sti...

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