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Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B…

Keshvara(L M),Isaacson(C C),Yankee(T M),Sara… J Immunol 1998-12-07

...Syk protein tyrosine kinase is an essential component of the B cell Ag receptor signaling pathway. Syk is phosphorylated...

Differential requirements for ZAP-70 in TCR signaling and T cell development.

Kadlecek(T A),van Oers(N S),Lefrancois(L),Ol… J Immunol 1998-11-18

...Syk/ZAP-70 family of protein tyrosine kinases is indispensable for normal lymphoid development. Syk is necessary for the...

Antigens varying in affinity for the B cell receptor induce differential B lymp…

Kouskoff(V),Famiglietti(S),Lacaud(G),Lang(P)… J Exp Med 1998-11-17

...syk or Igalpha, was highly affinity dependent, whereas the ability to stimulate Lyn phosphorylation was less so. These d...

Regulation of antigen receptor signal transduction by protein tyrosine kinases.

Chan(A C),Shaw(A S) Curr Opin Immunol 1997-01-31

...Syk protein tyrosine kinases and the structure of this complex was solved. In addition, possible mechanisms of activatio...

syk kinase activation by a src kinase-initiated activation loop phosphorylation…

El-Hillal(O),Kurosaki(T),Yamamura(H),Kinet(J… Proc Natl Acad Sci U S A 1997-04-07

...syk activation loop by both src family kinases and other molecules of activated syk, suggesting that syk activation occu...

Altered patterns of tyrosine phosphorylation and Syk activation for sterically …

Harris(N T),Goldstein(B),Holowka(D),Baird(B) Biochemistry 1997-03-25

...Syk occurs at the higher (DCT)2-cys concentrations in parallel with beta phosphorylation but does not occur in its absen...

Antigen receptor function in chronic lymphocytic leukemia B cells.

Lankester(A C),Schijndel(G M),Pakker(N G),Va… Leuk Lymphoma 1997-08-19

...syk, which is a key enzyme for the early signalling through the BCR, were found to be markedly lower in non-proliferatin...

Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic le…

Amoui(M),Dráberová(L),Tolar(P),Dráber(P) Eur J Immunol 1997-03-05

...Syk/ZAP-family PTK p72(syk) (Syk). Early activation events involve increased activity of Lyn and Syk kinases and their t...

Signaling by adhesion in human neutrophils: activation of the p72syk tyrosine k…

Yan(S R),Huang(M),Berton(G) J Immunol 1997-03-05

...syk). We also found that p72(syk)-autophosphorylating kinase activity was enhanced, and a fraction of p72(syk) was trans...

Large scale isolation of intact rat basophilic leukemia (RBL-2H3) cells.

Hamawy(M M),Siraganian(R P) J Immunol Methods 1997-03-13

...Syk. This procedure should prove useful for the isolation and characterization of cellular molecules important for mast ...

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