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Regulation of IL-2 signaling.

Higuchi(M),Asao(H),Tanaka(N),Oda(K),Takeshit… Leukemia 1997-08-07

...Syk are known to participate in IL-2-mediated intracellular signal transduction. Jak1, Lck and Syk are associated with t...

Shc contains two Grb2 binding sites needed for efficient formation of complexes…

Harmer(S L),DeFranco(A L) Mol Cell Biol 1997-07-24

...Syk induces binding of Grb2 to Shc, suggesting that Syk phosphorylates Shc in stimulated B cells. Surprisingly, Syk-phos...

Molecular mechanisms in B cell antigen receptor signaling.

Kurosaki(T) Curr Opin Immunol 1997-07-29

...Syk, and Btk in BCR signal transduction and B cell development. In addition, the interactions of these kinases and their...

Role of Tyr518 and Tyr519 in the regulation of catalytic activity and substrate…

Couture(C),Williams(S),Gauthier(N),Tailor(P)… Eur J Biochem 1997-07-28

...Syk is rapidly phosphorylated on tyrosine residues. We have previously reported that Syk expressed in COS cells is predo...

Identification of phosphopeptide ligands for the Src-homology 2 (SH2) domain of…

Gram(H),Schmitz(R),Zuber(J F),Baumann(G) Eur J Biochem 1997-08-14

...Syk. Selection of binding motifs was carried out by interaction of the library with the recombinant SH2 domain of Grb2 e...

CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of …

Kitanaka(A),Ito(C),Coustan-Smith(E),Campana(… J Immunol 1997-07-14

...syk, c-cbl, and phospholipase C-gamma and activates phosphatidylinositol 3-kinase (PI3-K). In the present study, we inve...

B cell antigen receptor desensitization: disruption of receptor coupling to tyr…

Vilen(B J),Famiglietti(S J),Carbone(A M),Kay… J Immunol 1997-07-14

...Syk. Most importantly, the Ig alpha and Ig beta components of desensitized receptors are not phosphorylated, and recepto...

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell…

Cheng(A M),Negishi(I),Anderson(S J),Chan(A C… Proc Natl Acad Sci U S A 1997-10-01

...Syk have no defect in the formation of DP thymocytes. Here we show that, in mice lacking both Syk and ZAP-70, DN thymocy...

Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa.

Ibarrola(I),Vossebeld(P J),Homburg(C H),Thel… Biochim Biophys Acta 1997-09-02

...Syk (immunoprecipitated from human neutrophils), but not in the presence of Fgr. Of the active kinases, only Lyn (mainly...

Diminished TCR signaling in cutaneous T cell lymphoma is associated with decrea…

Fargnoli(M C),Edelson(R L),Berger(C L),Chime… Leukemia 1997-09-04

...Syk, and a slight decrease in the specific activity of Lck kinases. Zap70 tyrosyl phosphorylation was reduced or undetec...

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