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DOT1L suppressed the proliferation of osteosarcoma cell line via modulating SYK…

Hu(F) Sci Rep 2025-07-02

...SYK, EGFR, p-SYK, p-EGFR, p-STING, p-TBK1, p-IRF3, P53, NLRP3, IL-1β, GSDMD, and apoptosis in Saos-2 cells, while inhibi...

Uptake system of lignin-derived aromatic acids in promising Sphingomonadaceae s…

Fujita(M),Hirano(R),Nagayoshi(K),Kamimura(N)… Sci Rep 2025-07-02

...SYK-6 can catabolize various lignin-derived aromatic compounds that can be used for this purpose. PcaK (Sl-PcaK), a memb...

Chemical Proteomics Identifies RBBP7 as a New E3 Ligase Supporting Targeted Pro…

Liu(Y),Yang(T),Huang(L),Li(S),Liu(T),Tan(Y),… Angew Chem Int Ed Engl 2025-09-01

...Syk, AKT, and GSK-3β, further highlighting the general feasibility of this approach. Importantly, the ynamide-containing...

Targeting neutrophil-driven inflammation in adult-onset still's disease: molecu…

Baek(IW),Kim(HA),Park(KS),Kim(KJ) Arthritis Res Ther 2025-07-01

...SYK demonstrated significant diffusion scores for neutrophil degranulation. In particular, CXCR1, CXCR2, and C5AR1 were ...

TYROBP modulates NFκB phosphorylation and SQSTM1 expression in macrophages duri…

Wu(W),Chen(W),Wan(S),Luo(X),Yang(D),Wang(C),… Res Vet Sci 2025-09-00

...SYK. TYROBP plays an important role in various immune responses, including inflammation and phagocytosis. Although the r...

Curcumenol Inhibits Mast Cells Activation in Ovalbumin-Induced Anaphylaxis Mode…

Kang(YM),Shim(KS),Chae(SW),Bok(SH),Park(DH),… Biomol Ther (Seoul) 2025-07-01

...Syk) in the FcεRI signaling pathway in BMMCs. Furthermore, curcumenol suppressed the activation of Akt, PLCγ1, and mitog...

Exopolysaccharides of Ganoderma lucidum Activate the NLRP3 Inflammasome, Modula…

Bürgel(PHM),de Castro(RJA),Basso(AM),Coelho(… Mycopathologia 2025-06-01

...Syk)/nuclear factor kappa-light-chain-enhancer of the activated B (NF-kB) axis. In addition, EPS stimulates IL-1β secret...

A new 3-arylbenzofuran derivative EIE-2 reestablishes Treg-dependent tolerance …

Li(P),Yin(X),Wen(X),Li(X),Wang(Y),Zhan(H),Ch… Front Immunol 2025-00-00

...Syk in Treg-dependent tolerance and the mechanism of EIE-2 were explored using western blotting, quantitative reverse tr...

TREM2 inhibits LPS-induced pyroptosis and inflammation by promoting mitophagy v…

Jiang(W),Fan(X),Wu(H),Song(J),Yang(C),Zhao(Z) Neurotoxicol Teratol 2025-00-00

...SYK), a downstream receptor kinase of TREM2 in microglia, results in exacerbated neuroinflammatory disease. This study f...

TREM2 Hit Discovery Using TRIC Technology: A Proof-of-Concept High-Throughput S…

Fuchs(N),Kuncewicz(K),El Gaamouch(F),Gabr(MT) bioRxiv 2025-06-06

...Syk phosphorylation in HEK293 cells co-expressing human TREM2 and its adaptor protein DAP12. These findings establish a ...

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