...TSC2 (tuberin) genes. Tubers are cortical developmental malformations in patients with tuberous sclerosis complex that a...
...TSC2, result in a similar disease phenotype by disrupting the normal interaction of their protein products, hamartin and...
...TSC2. Cells undergo bi-allelic inactivation of either gene to give rise to tumors in a classic tumor suppressor "two-hit...
...TSC2, encoding hamartin and tuberin, respectively. The pathogenesis of subependymal giant cell astrocytomas in tuberous ...
...TSC2. Tumorogenesis is triggered by the loss of second functional gene copy, mostly accompanied by loss of heterozygosit...
...Tsc2 tumor suppressor gene and provides a valuable experimental model to characterize the function of the Tsc2 gene prod...
Functional inactivation of tuberous sclerosis 2 gene (Tsc2) leads to renal carcinogenesis in the hereditary renal carcin...
The tuberous sclerosis gene products Tsc1 and Tsc2 behave as tumor suppressors by restricting cell growth, a function co...
...tsc2, mapped to the distal tip of the short arm of chromosome 2B. This gene was responsible for the effects of a major Q...
...TSC2 GAP activity. We demonstrated a novel catalytic mechanism of the TSC2 GAP and Rheb that TSC2 uses a catalytic "aspa...
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