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Tyrosine phosphorylation of the Fc receptor gamma-chain in collagen-stimulated …

Gibbins(J),Asselin(J),Farndale(R),Barnes(M),… J Biol Chem 1996-09-03

...Syk and phospholipase Cgamma2 are early events in collagen-induced activation. We recently proposed that collagen-signal...

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activat…

Takata(M),Kurosaki(T) J Exp Med 1996-08-29

...Syk is also required for the BCR-induced PLC-gamma 2 activation, our findings indicate that PLC-gamma 2 activation is re...

Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE rec…

Zhang(J),Berenstein(E H),Evans(R L),Siragani… J Exp Med 1996-08-29

...Syk, a cytoplasmic protein tyrosine kinase. To examine the role of Syk in the Fc epsilon RI signaling pathway, we identi...

BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells.

Uckun(F M),Waddick(K G),Mahajan(S),Jun(X),Ta… Science 1996-09-10

...syk genes did. Introduction of the wild-type, or a SRC homology 2 domain or a plecstrin homology domain mutant (but not ...

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase …

Dikic(I),Tokiwa(G),Lev(S),Courtneidge(S A),S… Nature 1996-11-12

...Syk. Here we show that lysophosphatidic acid (LPA) and bradykinin induce tyrosine phosphorylation of Pyk2 and complex fo...

Protein kinase C mu (PKC mu) associates with the B cell antigen receptor comple…

Sidorenko(S P),Law(C L),Klaus(S J),Chandran(… Immunity 1996-12-04

...Syk and phospholipase C-gamma 1/2 (PLC gamma 1/2). In vitro phosphorylation of fusion proteins showed that both Syk and ...

Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Sy…

Narula(S S),Yuan(R W),Adams(S E),Green(O M),… Structure 1996-03-28

...Syk-C plays a unique role in the intact Syk protein. The determinants of the binding affinity and selectivity of Syk-C m...

CD38 signal transduction in human B cell precursors. Rapid induction of tyrosin…

Silvennoinen(O),Nishigaki(H),Kitanaka(A),Kum… J Immunol 1996-04-23

...syk and increased syk kinase activity. CD38 dimerization also induced tyrosine phosphorylation of phospholipase C-gamma ...

Wortmannin blocks lipid and protein kinase activities associated with PI 3-kina…

Barker(S A),Caldwell(K K),Hall(A),Martinez(A… Mol Biol Cell 1996-02-06

...Syk, and stimulates secretion, membrane ruffling, spreading, pinocytosis, and the formation of actin plaques implicated ...

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and …

van Oers(N S),Killeen(N),Weiss(A) J Exp Med 1996-07-16

...Syk/ZAP-70 family of protein tyrosine kinases (PTK) are required for T cell receptor (TCR) functions. We provide evidenc...

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