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Fasting-induced physiological remodeling alleviated fatty liver in laying hen...

Gong(Y),Zeng(Q),Geng(X),Zhang(J),Kang(X),T... Poult Sci 2026-06-00

...ACAT2 decreased, while the decomposition gene ACSL1 increased (p < 0.05). Western Blot further confirmed enhanced expres...

Methyldopa reduces plasma bile acid concentrations in a murine model of estro...

Manna(DF),Lastuvkova(H),Schreiberova(J),Ja... Biochem Pharmacol 2026-08-25

...Acat2 expression, indicating altered cholesterol handling that may limit substrate availability for BA synthesis. In con...

Mult omics reveal the mechanism of solid dispersion of genistein in alleviati...

Liu(D),Guo(H),Yang(Y),He(X),Zhao(X) Poult Sci 2026-04-00

...ACAT2 within this pathway, while downregulating the expression of ME1. The underlying mechanism may involve the inhibiti...

Integrative metabolomic and transcriptomic analysis reveals stage-specific sh...

Li(J),Xu(Y),Ren(P),Xiong(X),Qiu(M),Yu(C),L... Anim Biotechnol 2026-12-00

...ACAT2), apovitellenin 1 (APOV1), vitellogenin 1 (VTG1), membrane-bound O-acyltransferase domain-containing protein 2 (MB...

A novel cholesterol-reducing mechanism of polygonati rhizoma: Dual action via...

Wang(X),Chen(M),Su(Y),Zhang(X),Chen(J),Hua... J Ethnopharmacol 2026-01-30

...ACAT2. Consistent with this interaction, CS greatly downregulated the mRNA and protein expression of ACAT2 in small inte...

Phytosterols Inhibit ACAT2-Catalyzed Cholesteryl Esterification in Caco-2 Cel...

Chen(Z),Chau(CHJ),Erickson(A),Ding(H),Huan... J Agric Food Chem 2025-08-06

...ACAT2), β-sitosterol and stigmasterol significantly lowered the level of cholesterol oleate in Caco-2 cells by 57.1 ± 0....

Peroxisome Proliferator-Activated Receptor Agonist IVA337 Alleviates Inflamma...

Li(N),Wu(S),Li(X),Yan(M),Ding(Y),Zhang(L),... Am J Pathol 2025-10-00

...ACAT2, as well as the inflammatory gene IL6. 3D mouse and human liver spheroid models of MASH, characterized by elevated...

Diatomaceous Earth Supplementation as a Bioavailable Silicon Source Modulates...

Redondo-Castillejo(R),Hernández-Martín(M),... Nutrients 2025-07-28

...ACAT2, and MTP, as well as reduced hepatic levels of MTP and LDLr, alongside increased levels of ABCG5/G8 and LXRα/β, in...

Therapeutic Potential of GeGen Decoction for the Treatment of Polycystic Ovar...

Qian(Y),Bayoude(A),Zhou(H),Shen(Y),Chai(C) FASEB J 2025-07-15

...ACAT2) and insulin-induced gene 1 (INSIG1), thereby enhancing the intracellular environment of KGN cells, promoting the ...

Dietary hispidulin ameliorated chemically-induced colitis by inhibiting epith...

Chen(D),Li(J),Li(X),Zhang(K),Zeng(S),Zhang... Food Funct 2025-09-15

...ACAT2 in vitro and AAV-mediated knockdown of ACAT2 in vivo substantially negated the effects of hispidulin on GPX4/GSH l...

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