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Design and optimization of N-(3-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)pheny...

Wang(Z),Mao(Z),Shen(C),Wang(R),Liu(B),Zhan... Eur J Med Chem 2026-04-05

...CTSL) inhibitors to reduce the expression of pro-inflammatory cytokines. Among these compounds, B5 exhibited dose-depend...

Placental Vulnerability to SARS-CoV-2: Viral Entry Pathways and Immune Activa...

Natarajan(M),Jayashankar(B),Nataraj(R) Viruses 2026-03-31

...CTSL and FURIN, within reproductive and placental tissues. The review further integrates documented mechanisms of cytoki...

Cathepsin L as a Driver of Tumour Invasion and a Novel Therapeutic Target in ...

Elshahri(I),Ervine(EHB),Musallam(TK),Alajo... Cancers (Basel) 2026-04-27

...CTSL, including selective inhibitors, multi-cathepsin approaches, CTSL-activated prodrugs and antibody-drug conjugate li...

K777 promotes functional recovery after spinal cord injury via the PI3K/AKT s...

Cheng(Y),Liang(C),Zhang(Y),Qi(Z),Zhang(B),... Biochem Biophys Res Commun 2026-07-02

...Ctsl were two pivotal genes that were associated with neuronal viability. K777, a Ctsb/Ctsl inhibitor, significantly imp...

Evolutionary diversification and immunoprofiling of cathepsin L toolkit in co...

Nayak(S),Kyslík(J),Majstorović(J),Dobai(T)... Front Cell Infect Microbiol None

...ctsl.1A/B are enriched at mucosal barriers, whereas ctslaA/B predominate in metabolic and systemic immune hubs and are t...

Transcriptomic characterization of platelet-rich fibrin-induced macrophage re...

Panahipour(L),Huang(X),Zampino(F),Miron(RJ... Front Immunol None

...CTSL, FAP, MMP3, MMP7, MMP9, MMP12, MMP14, MMP19, and MRC2). In contrast, PRF exposure in THP-1 cells primarily enriched...

Investigation of mRNA expressions in nasopharyngeal and oropharyngeal swab sa...

Çaykara Peran(B),Öztürk(G),Pençe(S),Yiyit(... BMC Infect Dis 2026-03-26

...CTSL gene expression in nasopharyngeal and oropharyngeal swab samples obtained from individuals during active SARS-CoV-2...

Single-cell fixed RNA profiling uncovers SEMA4D and LMCD1 as therapeutic targ...

Duc(PM),Thuy(LTT),Hai(H),Van Bao(T),Ha(NT)... JHEP Rep 2026-05-00

...Ctsl), fenestrae restoration in liver sinusoidal endothelial cells, anti-inflammatory Kupffer cells, reduced fibrogenic ...

CD74-Targeted Cathepsin-Inhibitor Antibody-Drug Conjugate Triggers Apoptosis ...

Abd-Elrahman(I),Khairi(N),Sinai-Turyansky(... Cells 2026-02-04

...CTSL+ DLBCL subgroup. This is the first study demonstrating coordinated overexpression of CD74 and CTSL and proposing th...

Cerebrospinal Fluid Proteome Reveals Dysregulation of Lysosomal and Axonal Pr...

Tang(H),Hu(J),Wu(Y),Gao(J),Wang(W),Zheng(X... J Proteome Res 2026-02-06

...CTSL, NPC2, and DNASE2, were significantly downregulated in the CSF of NS patients, and spNS patients presented a high C...

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