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Transsulfuration links aspartate-asparagine metabolism and redox homeo-stasis t…

Milosevic(M),Dmytruk(K),Alghadi(A),Jakoube(P… bioRxiv 2026-07-13

...GOT2, the cytosolic and mitochondrial aspartate aminotransferases essential for as-partate production and malate-asparta...

Integrated molecular mechanisms of salinity response in Apostichopus japonicus:…

Chen(J),Zhao(Y),Li(N),Wang(H),Wu(X),Wang(B),… Mar Biotechnol (NY) 2026-08-10

...Got2), Aconitase 2 (Aco2), and RNA Polymerase II Associated Protein 2 (Rpap2). Salinity sensing initiates GPCR-mediated ...

Neurotoxicity Mechanisms of Per- and Polyfluoroalkyl Substances: An Integrated …

Jiang(Z),Wei(C),Ma(A) Neurotox Res 2026-01-31

...GOT2) underlying the toxicity mechanism. Exposure to PFOA and PFOS leads to reduced brain volume - neurotoxicity at the ...

GOT2: a moonlighting enzyme at the crossroads of cancer metabolism and theranos…

Hu(J),Liu(Q),Ren(Q),He(W),Hou(J),Wang(X),Shu… Front Immunol 2025-00-00

...GOT2 as a potential target for cancer diagnosis and therapy. This review discusses GOT2's moonlighting roles and its cli...

BIRC3 deficiency blocks the ubiquitination and degradation of GOT2 to impede an…

Zhang(Q),Sheng(H),Ping(D),Gao(J) J Pathol 2025-10-00

...GOT2, leading to elevated GOT2 protein levels, which in turn facilitated CD8+ T-cell exhaustion and ultimately compromis...

Deletion of Skeletal Muscle Mitochondrial Glutamic-Oxaloacetic Transaminase (GO…

Fink(BD),Som(R),Yu(L),Sivitz(WI) FASEB J 2025-07-31

...GOT2KO and WT mitochondria, and oxaloacetate was not detectable. In summary, GOT2 and OAA mediate complex II respiration...

A mitochondrial-related gene signature predicts prognosis and immunotherapy res…

Shu(H),Li(R),Tang(X),Zhang(Q) Sci Rep 2025-07-14

...GOT2, and TOMM40L) that were markedly overexpressed in HCC tissues and strongly associated with adverse prognosis. MRGs-...

BDH1 acetylation at K116 modulates milk fat production in dairy goats.

Xiong(T),Chen(C),Gong(X),Han(C),Tian(M),Luo(… Res Sq 2025-07-29

...GOT2, BDH1, ACSS1, STAT5B, FABP5, and GPAM were identified as candidates potentially involved in milk protein synthesis,...

Glucose-induced STUB1-GOT2 axis promotes aspartate synthesis and mitochondrial …

Xiong(Y),Dong(Q),Hu(H),Li(Z),Zhan(X),Zheng(F… Cell Death Dis 2025-07-12

...GOT2 axis. Collectively, our findings identify that STUB1-GOT2 axis is an important regulator for maintaining Asp synthe...

Elucidating the protective mechanisms of umbilical cord mesenchymal stem cells …

Zhang(J),Sun(F),Yao(J),Zhang(J),Wu(X),Xu(Y),… Front Cell Dev Biol None

...Got2 was associated with amino acid biosynthesis, while both Got2 and Maoa were involved in phenylalanine metabolism. Fu...

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