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Xia(D),Gu(L),Yang(L),Hu(J),Xu(X),Jiang(D),... Metabolites 2026-08-03

...IAPP-induced cytotoxicity. Mass spectrometric analysis revealed the formation of HPA-IAPP oligomer complexes (n < 4), su...

Plesner(A),Cao(P),Raleigh(DP),Abedini(A) Proc Natl Acad Sci U S A 2026-08-11

Aggregation of islet amyloid polypeptide (IAPP) to form amyloid contributes to β-cell dysfunction in type 2 diabetes, ye...

Knapton(AE),Verma(N),Kotiya(D),Sowton(AP),... Compr Physiol 2026-10-00

...IAPP) in the setting of insulin resistance and type 2 diabetes (T2D) promotes systemic oligomerization and tissue deposi...

Iglesias-Fortes(S),García-Aguilar(A),Garcí... Front Endocrinol (Lausanne) None

...IAPP (TghIAPP), fed either a standard diet (STD) or a high-fat diet (HFD), and evaluated the therapeutic potential of re...

Zheng(H),Yuan(Y),Zhang(N),Zhang(H),Duan(S)... Neurobiol Dis 2025-10-01

...IAPP fibrils, we observed IAPP aggregates transfer between neurons via tunneling nanotubes (TNTs). RNA-seq analysis demo...

Carvalho(A),Pougy(KC),Pinheiro(AS),Cukierm... ACS Omega 2025-07-22

...IAPP or amylin). This peptide can bind to physiological metal ions such as copper-(II), which enhances its aggregation a...

Zhao(F),Lv(J),Yang(M),Zhang(F),Zhang(C),Wa... Bioorg Chem 2025-09-00

...IAPP aggregation, thereby offering therapeutic the prevention and treatment of T2DM. Recombinant IAPP (optimally express...

Khalifa(J),Sulaimon(R),Côté-Cyr(M),Nguyen(... Biochemistry 2025-08-19

...IAPP. Furthermore, corilagin provided significant cytoprotective effects against IAPP-induced cytotoxicity and membrane ...

De Carufel(Carole Anne),Nguyen(Phuong Tran... Biopolymers 2016-04-22

...IAPP amyloidogenesis remains unclear as well as the implications of cell surface GAGs in IAPP-mediated cytotoxicity. The...

Liu(Feng),Zhen(Jia),Lei(Min-Xiang),Chen(Hu... Zhongguo Dang Dai Er Ke Za Zhi 2016-04-23

...IAPP and Glut2, were expressed in differentiated cells. The proteins of insulin, C-peptide and Somastatin were expressed...