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Bousch(C),Bérubé(F),Babych(M),Ongeri(S),Bo... Int J Mol Sci 2026-03-12

...IAPP derivatives for the treatment of metabolic disorders. Accordingly, elucidating the molecular mechanisms by which IA...

Yoo(YM),Joo(SS) Int J Mol Sci 2026-03-23

...IAPP or amylin) within pancreatic β-cells. IAPP is also a neuropancreatic hormone that plays a significant role in Alzhe...

Oh(Y),Palanikumar(L),Howarth(M),Maity(D),A... Biochemistry 2026-04-21

Islet amyloid polypeptide (IAPP) is a 37-residue peptide hormone copackaged and cosecreted with insulin by pancreatic β-...

Valshon(K),Kondrot(K),Uehara(H),Alexander(... Int J Mol Sci 2026-03-26

...IAPP aggregates, ultimately leading to apoptosis. A small but growing body of research also links IAPP-mediated proteoto...

Panek(S),Van Baelen(AC),Volta(BD),Dutta(SB... J Med Chem 2026-03-26

...IAPP, leading to poor specificity. We report a peptide-guided late-stage diversification strategy to generate BODIPY-bas...

Alghrably(M),Sukareh(F),Khamis(LM),Kahfi(J... Front Public Health None

...IAPP, and β2-microglobulin-while older adults also accumulate comorbidities (chronic kidney disease, diabetes, neurodege...

Xia(D),Gu(L),Yang(L),Hu(J),Xu(X),Jiang(D),... Metabolites 2026-08-03

...IAPP-induced cytotoxicity. Mass spectrometric analysis revealed the formation of HPA-IAPP oligomer complexes (n < 4), su...

LeMasters(BE),Fields(CR),Lomont(JP),Chalya... Proc Natl Acad Sci U S A 2026-02-03

...IAPP, and their IAPP does not form this β-sheet structure. Pig IAPP forms oligomers, but with a different structure that...

Lin(J),Zhang(YP),Chia(S),Klenerman(D),Sorm... Chem Sci 2026-02-04

...IAPP aggregation and assessed their binding affinity towards different IAPP species. Then, we utilized these constructs ...

Babych(M),Nguyen(PT),Bérubé(F),Bourgault(S... ACS Chem Biol 2026-01-16

...IAPP) from aggregation and amyloid-associated toxicity. IAPP is the major component of insoluble amyloid deposits found ...