Biesbrock(KV),Haws(SA),Cormaty(H),Sridhara... bioRxiv 2026-05-10

...MAT2A, -GDH, and -AHCY) were used to modulate nuclear levels of essential co-substrates involved in histone (de)acetylat...

Chen(Y),Liu(Y),Zhu(Z),Ding(A),Suo(Y),Wang(... iScience 2026-09-18

...MAT2A-targeting siRNA or the inhibitor AG-270, we characterized MAT2A-driven metabolic rewiring. In fatty acid biosynthe...

Arter(ZL),Shim(JSG),Park(C),Waliany(S),Lim... Cancer Treat Rev 2026-08-29

...MAT2A-PRMT5 axis. This review summarizes recent advances in understanding MTAP biology, including the PRMT5/MAT2A feedba...

Bindl(D),Suga(H) J Am Chem Soc 2026-07-08

...MAT2A. The selected peptides contained structurally critical pcAgl motifs, inhibited the enzyme (best IC50 = 9 μM), and ...

Liu(Y),Chrysovergis(K),Johnson(KL),William... bioRxiv 2026-07-06

...MAT2A and CBS, helps maintain methionine homeostasis in response to methionine starvation. These findings identify m6A R...

Ohayon(H),Hija(A),Bilder(A),Capucha(T),Akr... Diagnostics (Basel) 2026-06-04

...MAT2A and PRMT5 inhibitors currently under clinical investigation. An occult primary site could not be fully excluded du...

Gao(M),Chen(S),Chen(Y),Han(Q),Li(D),Li(W),... Anim Nutr 2026-09-00

...MAT2A relative mRNA expression in liver and ovarian (P < 0.05). Compared with the CON group, Met supplementation also in...

Dela Cruz(FS),You(D),Feinberg(TY),Brosius(... Cancer Res 2026-07-02

...MAT2A inhibitor in MTAP-deficient PDXs. Universal model creation also allowed for experimental validation of therapeutic...

Wei(Q),Wang(Y),Hou(T),Wang(Q),Lu(B),Zhang(... J Thorac Oncol 2026-07-06

...MAT2A inhibition.

Chen(X),Xiao(L),Zhou(Y),Wu(Z),Xu(X),Qiu(T)... Cell Signal 2026-11-00

...MAT2A), a SAM-producing enzyme, as a glucose-responsive NSUN2 partner. MAT2A knockout reproduced the signaling defect. T...