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An allosteric inhibitor of protein arginine methyltransferase 3.

Siarheyeva(Alena),Senisterra(Guillermo),Al... Structure 2012-12-26

...PRMT3 in complex with compound 1 as well as kinetic analysis reveals an allosteric mechanism of inhibition. Mutating PRM...

Fluorescence-based methods for screening writers and readers of histone methy...

Allali-Hassani(Abdellah),Wasney(Gregory A)... J Biomol Screen 2012-06-25

...PRMT3, SETD7, and SUV39H2 as well as for screening against libraries of small molecules to identify enzyme inhibitors. T...

Proteomic dissection of the von Hippel-Lindau (VHL) interactome.

Lai(Yanlai),Song(Meihua),Hakala(Kevin),Wei... J Proteome Res 2012-03-05

...PRMT3. Our analysis of the VHL19 interactome also uncovered that VHL19 displays an affinity to collagens and their biosy...

Formulating a fluorogenic assay to evaluate S-adenosyl-L-methionine analogues...

Wang(Rui),Ibáñez(Glorymar),Islam(Kabirul),... Mol Biosyst 2012-05-25

...PRMT3, CARM1, SUV39H2, SET7/9, SET8, G9a and GLP1). The fluorogenic assay was further implemented to screen the PMTs aga...

Molecular characterization, phylogenetic analysis and expression patterns of ...

Yeh(Hung-Yueh),Klesius(Phillip H) Fish Physiol Biochem 2012-11-08

...PRMT3 and PRMT5 encode 292 and 563 amino acids, respectively. By comparison with the human counterparts, each channel ca...

[Expression of protein arginine N-methyltransferases in E3 rat models of acut...

Sun(Qing-zhu),Jiao(Fang-fang),Yang(Xu-dong... Nan Fang Yi Ke Da Xue Xue B... 2011-09-22

...PRMT3 (P<0.05) and PRMT5 (P<0.05) were significantly increased, but the expression of PRMT4 gene (P<0.05) was significan...

Discovery of peptidylarginine deiminase-4 substrates by protein array: antago...

Guo(Qin),Bedford(Mark T),Fast(Walter) Mol Biosyst 2011-09-28

...PRMT3). As in other systems, crosstalk is observed; citrullination and methylation modifications are found to be antagon...

Structural basis for CARM1 inhibition by indole and pyrazole inhibitors.

Sack(John S),Thieffine(Sandrine),Bandiera(... Biochem J 2011-07-18

...PRMT3. Together, the structural and biophysical information should aid in the design of both potent and specific inhibit...

Tyrosine 87 is vital for the activity of human protein arginine methyltransfe...

Handrkova(Helena),Petrak(Jiri),Halada(Petr... Biochim Biophys Acta 2011-03-15

...PRMT3 properties, we constructed two additional PRMT3 variants, Tyr87Phe and Tyr87Glu PRMT3, mimicking non-phosphorylate...

PRMT3 is essential for dendritic spine maturation in rat hippocampal neurons.

Miyata(Shingo),Mori(Yasutake),Tohyama(Masaya) Brain Res 2010-12-22

...PRMT3 mRNA and then we examined the morphological and functional effects of neuronal PRMT3 depletion. PRMT3-defective ne...

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