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The ral exchange factor rgl2 promotes cardiomyocyte survival and inhibits car...

Scotland(Rebecca L),Allen(Leah),Hennings(L... PLoS One 2014-04-28

...RalGDS) proteins are Ras-interacting proteins that are upregulated by hypertrophic stimuli. The Ral guanine nucleotide d...

Optimizing electrostatic field calculations with the adaptive Poisson-Boltzma...

Ritchie(Andrew W),Webb(Lauren J) J Phys Chem B 2014-11-04

...RalGDS, both in its monomeric form as well as when docked to four different constructs of the protein Rap, and compared ...

The guanine nucleotide exchange factor Rlf interacts with SH3 domain-containi...

Popovic(Milica),Jakobi(Arjen J),Rensen-de ... J Struct Biol 2014-03-20

...RalGDS family of guanine nucleotide exchange factors and stabilises the orientation of the REM-domain relative to the CD...

Structural basis for the interaction of the adaptor protein grb14 with activa...

Qamra(Rohini),Hubbard(Stevan R) PLoS One 2014-05-14

...RalGDS and Raf1 but with important distinctions. The integrated RA-PH structural unit in Grb7-10-14 is also found in a s...

Ras effector mutant expression suggest a negative regulator inhibits lung tum...

Vandal(Guillaume),Geiling(Benjamin),Dankor... PLoS One 2014-12-18

...RalGDS; the G37 mutant binds to RalGDS and not Raf or PI3K and the C40 mutant is specific to PI3K. We designed lentivira...

RASSF2 hypermethylation is present and related to shorter survival in squamou...

Guerrero-Setas(David),Pérez-Janices(Noemí)... Mod Pathol 2014-03-11

...RalGDS/AF-6) domain family member 2 (RASSF2) is a gene involved in the progression of several human cancers, including b...

The peripheral blood transcriptome reflects variations in immunity traits in ...

Mach(Núria),Gao(Yu),Lemonnier(Gaëtan),Leca... BMC Genomics 2014-07-21

...RALGDS), phagocytosis (ALOX12) or CD4⁻/CD8⁺ cell count (GNLY, KLRG1 and CX3CR1). On average, these biomarkers performed ...

Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 regul...

van Hooren(K W E M),van Breevoort(D),Ferna... J Thromb Haemost 2014-11-14

...RalGDS. Functional involvement of candidate proteins in WPB release was determined by RNA interference (RNAi)-mediated k...

Genetic and epigenetic alterations in primary colorectal cancers and related ...

Miranda(Elena),Bianchi(Paolo),Destro(Annar... Cancer 2013-02-20

...RalGDS/AF-6) domain family member 1 protein (RASSF1a), E-cadherin, and cyclin-dependent kinase inhibitor 2A (p16INK4a) i...

Depletion of K-Ras promotes proteasome degradation of survivin.

Tecleab(Awet),Sebti(Saïd M) Cell Cycle 2013-08-01

...RalGDS/Ral but not PI3K/Akt and Raf-1/Mek effector pathways. Furthermore, the ability of mutant K-Ras to induce anchorag...

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