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Fasudil Protects Against Diclofenac-Induced Hepatorenal and Gastric Injury vi...

Al-Baldawi(AH),Samaha(MM),Zaghloul(MS) J Xenobiot 2026-08-02

...ROCK2/TLR4/SIRT1 axis. Five separate cohorts were established using thirty male Sprague-Dawley rats. Alongside a normal ...

Insulin pathway components and insulin effects on rho kinase in rat colon.

Al-Shboul(OA),Al-Dwairi(AN),Bani Hamad(AK)... Mol Biol Rep 2026-07-29

...ROCK2 isoforms were greater than IRB, IRS1, p110β, and ROCK1 isoforms respectively. Insulin significantly reduced acetyl...

CerS2/ceramide C24:1/ROCK2 signaling-mediated angiogenesis protects against i...

Fan(J),Li(Q),Zhang(D),Zhang(Y),Tan(H),Lv(W... Biochem Pharmacol 2026-07-29

...ROCK2 to activate HIF-1α, thereby up-regulating the expression of vascular endothelial growth factor (VEGF) and increasi...

Extracellular Aβ42 Oligomers Induce ROCK2 Hyperactivation Through Dual Mediat...

Zheng(C),Wen(K),Li(H),Zhang(T),Zhang(Y) Cells 2026-07-30

...ROCK2 through RhoA and granzyme B (GzmB) mediation, with GzmB-mediated ROCK2 activation constituting a significant compo...

Structure-based discovery of novel ROCK2 inhibitors using integrated virtual ...

Gupta(SRR),Rameshwari(R),Singh(IK),Rustagi(V) In Silico Pharmacol None

...ROCK2), a key regulator in the Ras homolog family member (Rho) GTPase signaling pathway, is implicated in tumor progress...

Blocking the RhoA/ROCK/cofilin/F-actin Pathway via Y27632 Protects Against ME...

Feng(L),Zhang(T),Du(Y),Qin(Y),Zhou(L),Bai(... Curr Med Chem 2026-08-11

...ROCK2, and cofilin and decreased F-actin expression in HsRPE cells. Blocking the RhoA/ROCK axis by a selective ROCK inhi...

Discovery of Deuterated 3,4-Dihydro-benzo[e][1,4]diazepine-2,5-dione Derivati...

Li(Y),Zhang(L),Xu(H),Huang(Y),Dai(Y),Zhu(Q... J Med Chem 2026-08-13

Rho-associated coiled-coil-containing kinase 2 (ROCK2) is a key regulator of cellular motility and invasion and represen...

Investigating the Cellular Activity and Differential Gene Expression of Human...

Yao(L),Bustamante-Fuchs(K),Cantu(K),Shippy(T) Neurochem Res 2026-08-14

...ROCK2, and PIP5K1A. These results demonstrate that incorporation of SPI into collagen-based nanofibers modulates astrocy...

Identifying ROCK2 as an intervention target for bilirubin encephalopathy.

Ke(B),Mao(L),Hu(M),Cui(Y),Chen(M),Wu(C),Gu... Fundam Res 2026-07-00

...ROCK2 inhibitors and Rock2+/- mice, we demonstrated that modulation of ROCK2 significantly alleviated bilirubin-induced ...

ROCK2 inhibition suppresses cytotoxic T lymphocyte-mediated platelet destruct...

Song(J),Ding(B),Liu(Q),Xie(A),Li(M),Song(X... Cell Biosci 2026-07-20

...ROCK2) is an emerging regulator of immune balance, but its role in pathogenic CTL activation in ITP remains undefined. H...

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