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Paeoniae Radix Alba-Chuanxiong Rhizoma herbal pair alleviates trigeminal nucl...

Liu(L),Feng(M),Liu(J),Cai(S),Cong(S),Xu(Y)... J Ethnopharmacol 2027-01-10

...ROCK2/NF-κB-related proteins and increased PPARγ expression. Among the constituents detected in the TNC, benzoylpaeonifl...

RhoGEF12 regulates endosomal SORL1-retromer and its inhibition is therapeutic...

Qureshi(YH),Williams(CA),Hajdu(I),Kannan(S... bioRxiv 2026-03-09

...ROCK2 (Rho-associated kinase 2) reduces SORL1's affinity to retromer. Since RhoGEF12 (Rho guanine nucleotide exchange fa...

Induction of adipocyte thermogenic program by Rho-associated coiled-coil cont...

Tai(HC),Li(X),Park(CJ),Alshaikh(A),Yu(B),C... iScience 2026-04-17

...ROCK2, the predominant ROCK isoform in adipocytes, in cold-induced thermogenesis is uncertain. Here, we show that ROCK2 ...

A20 enhances the migration and metastasis of gastric cancer cells by promotin...

Kuo(YT),Wang(HC),Shan(YS) Cell Death Discov 2026-03-28

...ROCK2 phosphorylation, which contributes to occludin degradation. PLA further showed that mutation of the OTU domain dis...

Tongfu-Xingshen Capsule ameliorates ischemic stroke by inhibiting pyroptosis-...

Lv(QH),Hu(T),Xu(JP),Xu(XY),Ouyang(J),Wu(D)... J Ethnopharmacol 2026-07-15

...Rock2/ASC-mediated pyroptosis, and regulated microglial activation. Further in vitro experiments demonstrated that TXC p...

Rho-associated kinase (ROCK)-associated proteins and genes-encoded proteins u...

Zakaria(MA),Rajab(NF),Chua(EW),Zawawi(MRA)... J Egypt Natl Canc Inst 2026-04-20

...ROCK2, and pMLC during LUSC progression via IHC and Western blot assays. Notably, RhoA, RhoB, and pMLC (MYL9) mRNA were ...

The role of Rho-associated coiled-coil kinases (ROCK) in cancer.

Zafrany(L),Wu(R),Melsaether(A),Waksal(SD),... Oncogene 2026-05-00

...ROCK2. The roles of ROCKs are context-dependent, varying by cell type and microenvironment and have been associated with...

Cyclic tensile stress restores chondrocyte homeostasis via integrin-FAK-RhoA/...

Yin(Z),Xie(L),Ma(J),Yang(Y),Zhang(X),Yu(G)... Biochem Biophys Res Commun 2026-06-04

...ROCK2 cascade, evidenced by increased FAK phosphorylation (Y397) and RhoA/ROCK2 expression. Crucially, FAK knockdown abo...

Cellular and Molecular Neuro-Bone Cell Interactions Drive Alveolar Bone Remod...

Fang(X),Liao(C),Wan(J),Jiang(C),Yi(Y),Wang... Int J Biol Sci None

...ROCK2, and Notch3. Sensory nerves function as primary initiators by releasing neuropeptides that promote osteoclastogene...

Taohong Siwu Decoction switches the detrimental/reparative phenotypes of astr...

Feng(X),Tang(L),Chen(H),Wu(J),Wei(L),Liu(Y... J Ethnopharmacol 2026-07-15

...ROCK2/Profilin-1 (PFN1) signals may be key regulators. This research investigated whether THSWD promoted post-stroke rem...

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