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Expansion of the phenotype in ZFX neurodevelopmental disorder in a family.

van der Tol(L),de Jong(M),Alders(M),Wilke(M)… Eur J Med Genet 2025-12-00

...ZFX variant. In this report, we present a male patient and his mother with a new likely pathogenic variant in the ZFX ge...

Application of restriction endonuclease enzymes for sex determination in select…

Özşensoy(Y) Mol Biol Rep 2025-10-17

...ZFX/Y). The PCR products were digested using 10 different REs (EcoRI, MspI, SmaI, AlwI, PstI, NdeI, HaeIII, TaqI, DdeI, ...

Pitavastatin overcomes multi-drug resistance in CRC and NSCLC by targeting the …

Zhai(YY),Wang(Q),Nong(QY),Gao(MY),Zhang(Y),X… Biochem Pharmacol 2025-11-00

...ZFX), and disrupts the NRP1-ZFX axis to reverse MDR. This study provides promising prospects for targeting the NRP1-ZFX ...

Transcription factor Zfx regulates tumor's evasion to T cell killing in immunot…

Kaufmann(U),Wang(J),Callow(MG),Fortin(JP),My… iScience 2025-11-21

...Zfx). Zfx knockout tumor cells are resistant to T cell killing both in vitro and in vivo. We demonstrate that Zfx regula...

The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglio…

Ansari(MN),Jha(SK),Khan(A),Rajput(K),Pandey(… PLoS Biol 2025-09-00

...ZFX) as a RICTOR-responsive transcription factor whose recruitment to the UGCG promoter is regulated by DNA methyltransf...

OVCH1 Antisense RNA 1 is differentially expressed between non-frail and frail o…

Abugessaisa(I),Manabe(RI),Kawashima(T),Tagam… Geroscience 2024-00-00

...ZFX-AS1 and OVCH1 Antisense RNA 1). The promoter region chr6:366,786,54-366,787,97;+ was DE and overlapping the longevit...

Distinct patterns of proteostasis network gene expression are associated with d…

Wellman(R),Jacobson(D),Secrier(M),Labbadia(J) Sci Rep 2024-00-02

...ZFX, CREB1 and ATF2, as well as markedly different survival outcomes. However, surprisingly, similar PN alterations in p...

Blockade of ZFX Alleviates Hypoxia-Induced Pulmonary Vascular Remodeling by Reg…

Tang(L),Zhou(X),Guo(A),Han(L),Pan(S) Cardiovasc Toxicol 2024-02-00

...ZFX. ZFX knockdown inhibited Glycolytic ability. ZFX strengthened the transcription activity of YAP1, thereby regulating...

Variants in ZFX are associated with an X-linked neurodevelopmental disorder wit…

Shepherdson(JL),Hutchison(K),Don(DW),McGilli… Am J Hum Genet 2024-00-07

...ZFX in cultured cells, suggesting a gain or loss of transcriptional activity. Additionally, a zebrafish model of ZFX los...

Mitochondrial-related hub genes in dermatomyositis: muscle and skin datasets-ba…

Wang(S),Tang(Y),Chen(X),Song(S),Chen(X),Zhou… Front Genet 2024-00-00

...ZFX with CMPK2 and LAP3, as well as SOX2 with LAP3 and IFI27, and AR with IFI27 and CMPK2. Conclusion: The mito-hub gene...

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