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TP53 BRCA1 CRISPR single-cell cancer

Yoon(Hae-Seong),Monks(Terrence J),Everitt(Je… Am J Physiol Renal Physiol 2002-08-08

...Tsc2(+/+)) and mutant Eker rats (Tsc2(EK/+)), only TGHQ-treated Tsc2(EK/+) rats developed renal tumors, indicating that ...

Kenerson(Heidi L),Aicher(Lauri D),True(Lawre… Cancer Res 2002-11-29

Disruption of the TSC1 or TSC2 gene leads to the development of tumors in multiple organs, most commonly affecting the k...

Radimerski(Thomas),Montagne(Jacques),Hemming… Genes Dev 2002-11-14

...TSC2. Here, we show that absence of Drosophila Tsc1/2 leads to constitutive dS6K activation and inhibition of dPKB, the ...

Martignoni(Guido),Bonetti(Franco),Pea(Mauriz… Am J Surg Pathol 2002-02-28

...TSC2 (16p13.3), are renal cysts and angiomyolipomas. Epithelial neoplasms are less common. The TSC2 gene lies adjacent t...

Noonan(Daniel J),Lou(Dingyuan),Griffith(Nico… Arch Biochem Biophys 2002-02-15

Mutations in the tuberous sclerosis 2 (TSC2) gene product have been genetically linked to the pathology of both tuberous...

Xu(H),Shen(J),Walker(C L),Kleymenova(E) DNA Seq 2002-08-14

...Tsc2) gene. Pkdl was found ubiquitously expressed in the normal rat tissues and the brain had a complex pattern of exon ...

Woods(Stacey A),Marmor(Eric),Feldkamp(Matthi… J Neurosurg 2002-10-11

...TSC2 gene. Tuberin functions as an inactivator of the small G protein rap1B (rap1-GAP) and, hence, loss of its expressio...

Zarei(M),Collins(V P),Chandran(S),Valler(D),… J Neurol Neurosurg Psychiatry 2002-10-23

...TSC2 gene.

Tee(Andrew R),Fingar(Diane C),Manning(Brenda… Proc Natl Acad Sci U S A 2002-12-04

...TSC2 genes, which encode the protein products hamartin and tuberin, respectively. Here, we show that hamartin and tuberi...

Jaeschke(Anja),Hartkamp(Joerg),Saitoh(Masao)… J Cell Biol 2002-11-22

...TSC2, whose gene products hamartin (TSC1) and tuberin (TSC2) constitute a putative tumor suppressor complex (TSC1-2; van...

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