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Clustering of Syk is sufficient to induce tyrosine phosphorylation and release …

Rivera(V M),Brugge(J S) Mol Cell Biol 1995-03-23

...syk (Syk), which binds to tyrosine-phosphorylated Fc epsilon RI. Clustering of Syk, as a result of its interaction with ...

Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine …

Mahajan(S),Fargnoli(J),Burkhardt(A L),Kut(S … Mol Cell Biol 1995-10-25

...Syk, led to Btk tyrosine phosphorylation and activation. Using a series of point mutations in Blk (a representative Src ...

Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities…

Johnson(S A),Pleiman(C M),Pao(L),Schneringer… J Immunol 1995-12-18

...syk family kinases in vivo and in vitro. All (p)2ITAMs, but not their nonphosphorylated counterparts, induced extensive ...

Protein tyrosine phosphatase activity associates with the high affinity IgE rec…

Swieter(M),Berenstein(E H),Siraganian(R P) J Immunol 1995-12-28

...Syk. These results strongly suggest that the IgE receptor-associated protein tyrosine phosphatase may regulate the stead...

The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta s…

van Oers(N S),von Boehmer(H),Weiss(A) J Exp Med 1995-12-04

...Syk/ZAP-70 family of protein tyrosine kinases. Stimulation of the pre-TCR complex led to the tyrosine phosphorylation of...

Syk mutation in Jurkat E6-derived clones results in lack of p72syk expression.

Fargnoli(J),Burkhardt(A L),Laverty(M),Kut(S … J Biol Chem 1995-12-21

...Syk protein tyrosine kinase previously found in other Jurkat cells was not detected. Upon further analysis it was determ...

Reconstitution of the B cell antigen receptor signaling components in COS cells.

Saouaf(S J),Kut(S A),Fargnoli(J),Rowley(R B)… J Biol Chem 1995-12-26

...Syk, Fyn), only Blk was able to phosphorylate and subsequently associate with cotransfected Ig alpha and Ig beta chimera...

Antigen receptor nonresponsiveness in chronic lymphocytic leukemia B cells.

Lankester(A C),van Schijndel(G M),van der Sc… Blood 1995-08-29

...syk was found to be considerably lower in nonresponsive B-CLL. Thus, absence of mitogenic responses upon BCR cross-linki...

A novel role for IgG-Fc. Transductional potentiation for human high affinity Fc…

Pfefferkorn(L C),van de Winkel(J G),Swink(S … J Biol Chem 1995-05-15

...Syk. Thus, the consequences of IgG-Fc binding were increases in aggregation-dependent phosphorylation of Fc gamma RI gam...

Purification of a major tyrosine kinase from RBL-2H3 cells phosphorylating Fc e…

Price(D J),Kawakami(Y),Kawakami(T),Rivnay(B) Biochim Biophys Acta 1995-05-03

...syk by inability to be precipitated by anti-syk antiserum and by partial peptide mapping. Cd gamma kinase was also disti...

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