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Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia …

McCaig(Alison M),Cosimo(Emilio),Leach(Michae… Br J Haematol 2012-06-08

...Syk(Y348) phosphorylation. Dasatinib inhibited calcium flux, phosphatidylinositol-3-kinase and mitogen-activated protei...

Marked differences in the signaling requirements for expression of CD203c and C…

MacGlashan(Donald) Int Arch Allergy Immunol 2012-12-24

...syk inhibitor, NVP-QAB205, showed a 5-fold lower potency for inhibiting expression of CD203c and CD11b than for CD63. Fi...

House dust mite-specific immunotherapy alters the basal expression of T regulat…

Pevec(Branko),Radulovic Pevec(Mira),Stipic M… Int Arch Allergy Immunol 2012-12-24

...Syk), phosphatidylinositol 3 kinase (PI3K) and SH2 domain-containing inositol phosphatase (SHIP) were quantified by real...

CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor s…

Bao(Musheng),Hanabuchi(Shino),Facchinetti(Va… J Immunol 2012-09-20

...Syk and FcεR1γ that was mediated by the E3 ubiquitin ligase Cbl. This led us to discover that, upon BDCA2 cross-linking,...

Altered BCR signalling quality predisposes to autoimmune disease and a pre-diab…

Königsberger(Sebastian),Prodöhl(Jan),Stegner… EMBO J 2012-10-25

...Syk promoter elements that disrupts wild-type Syk expression. Kinase replacement severely compromised Erk1/2-mediated su...

HIV delays IFN-α production from human plasmacytoid dendritic cells and is asso…

Lo(Calvin C),Schwartz(Jordan A),Johnson(Dyla… PLoS One 2012-10-22

...SYK phosphorylation. We find that compared to Influenza, HIV induces the activation of the SYK pathway. Thus, HIV delays...

Syk kinase is phosphorylated in specific areas of the developing nervous system.

Hatterer(Eric),Benon(Aurélien),Chounlamountr… Neurosci Res 2012-04-09

...Syk family tyrosine kinases, Syk and ZAP-70, being a critical step in this process, we conducted a thorough analysis of ...

G(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromb…

Bhavaraju(Kamala),Lakhani(Parth R),Dorsam(Ro… PLoS One 2012-04-02

...Syk and FAK (Focal Adhesion Kinase) that are known to be activated by integrins. c-Src and Syk kinase did not play a rol...

T cell activation by terminal complex of complement and immune complexes.

Chauhan(Anil K),Moore(Terry L) J Biol Chem 2012-01-09

...Syk, Src, and Lck, were phosphorylated and organized in a synapse-like structure. The cytoskeleton formed F-actin spindl...

Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis …

Yu(Tao),Ahn(Hyo Min),Shen(Ting),Yoon(Keejung… J Ethnopharmacol 2012-02-14

...Syk), p38, and transforming growth factor β-activated kinase 1 (TAK1). Finally, orally administered Pa-EE clearly amelio...

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