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Molecular genetic advances in tuberous sclerosis.

Cheadle(J P),Reeve(M P),Sampson(J R),Kwiatko… Hum Genet 2000-10-27

...TSC2, the genes responsible for the disorder, through to gaining insights into the functions of their protein products h...

A novel gene "Niban" upregulated in renal carcinogenesis: cloning by the cDNA-a…

Majima(S),Kajino(K),Fukuda(T),Otsuka(F),Hino… Jpn J Cancer Res 2000-12-13

...Tsc2 gene mutant (Eker) rats. One gene, selected for further investigation, was named "Niban" "second" in Japanese), bec...

Identification of functional elements in the bidirectional promoter of the mous…

Ikeda(S),Mochizuki(A),Sarker(A H),Seki(S) Biochem Biophys Res Commun 2000-09-08

...TSC2/Tsc2, in a head-to-head orientation. To clarify the regulation of these divergent genes, we studied the promoter ac...

Simultaneous loss of hamartin and tuberin from the cerebrum, kidney and heart w…

Mizuguchi(M),Ikeda(K),Takashima(S) Acta Neuropathol 2000-07-17

...TSC2 gene. The clinical manifestations of mutations of the two genes are hardly distinguishable, for reasons as yet unkn...

Similarities and differences in the subcellular localization of hamartin and tu…

Murthy(V),Haddad(L A),Smith(N),Pinney(D),Tys… Am J Physiol Renal Physiol 2000-06-12

...TSC2 genes, coding hamartin and tuberin, respectively. Immunofluorescence analysis of tuberin and hamartin performed her...

Enhanced cardiomyocyte DNA synthesis during myocardial hypertrophy in mice expr…

Pasumarthi(K B),Nakajima(H),Nakajima(H O),Ji… Circ Res 2000-06-20

...TSC2-deficient cells. Surprisingly, targeted expression of the most potent TSC2 cDNA to the heart did not perturb cardia...

Monotypic epithelioid angiomyolipoma of the liver.

Yamasaki(S),Tanaka(S),Fujii(H),Matsumoto(T),… Histopathology 2000-06-16

...TSC2 region or 12 other chromosomal regions. The patient is free of disease over 1 year after the operation.,We consider...

The TSC1 gene product, hamartin, negatively regulates cell proliferation.

Miloloza(A),Rosner(M),Nellist(M),Halley(D),B… Hum Mol Genet 2000-10-27

...TSC2 tumor suppressor gene. The TSC1 gene on chromosome 9q34 encodes a 130 kDa protein named hamartin, and the TSC2 gene...

[DNA diagnosis in Czech patients with tuberous sclerosis].

Vrtĕl(R),Santavá(A),Santavý(J),Polák(P),Krej… Cas Lek Cesk 2000-08-11

...TSC2). The aim of the study is to adopt a diagnosis of the disease on DNA level.,111 DNA samples were collected from 45 ...

Promotion by sodium barbital induces early development but does not increase th…

Wolf(D C),Goldsworthy(T L),Janszen(D B),Hard… Carcinogenesis 2000-08-23

Induced cell proliferation is important in the mode of action of many non-genotoxic renal carcinogens. Since Tsc2 mutant...

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