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A Conditional Knockout Mouse Model Reveals That Calponin-3 Is Dispensable for E…

Flemming(Alexandra),Huang(Qi-Quan),Jin(Jian-… PLoS One 2016-03-15

...Syk-dependent manner, suggesting a putative role in pre-BCR signaling. To investigate this in vivo, we generated a floxe...

Celastrol inhibits inflammatory stimuli-induced neutrophil extracellular trap f…

Yu(Y),Koehn(C D),Yue(Y),Li(S),Thiele(G M),He… Curr Mol Med 2016-03-24

...SYK) and the concomitant phosphorylation of mitogen-activated protein kinase kinase (MAPKK/MEK), extracellular-signal-re...

An atypical IgM class platelet cold agglutinin induces GPVI-dependent aggregati…

Sánchez Guiu(I M),Martínez-Martinez(I),Martí… Thromb Haemost 2016-06-14

...Syk, and by a soluble GPVI-Fc fusion protein. GPVI-deficient platelets were not activated by patient plasma. These data ...

The protective effect of p16(INK4a) in oral cavity carcinomas: p16(Ink4A) dampe…

Isayeva(Tatyana),Xu(Jie),Ragin(Camille),Dai(… Mod Pathol 2016-02-24

...Syk might increase MUC1 phosphorylation, leading to the observed decreased MMP1 expression.

Introduction of chemically labile substructures into Arabidopsis lignin through…

Tsuji(Yukiko),Vanholme(Ruben),Tobimatsu(Yuki… Plant Biotechnol J 2016-04-05

...SYK-6 possesses a Cα-dehydrogenase (LigD) enzyme that has been shown to oxidize the α-hydroxy functionalities in β-O-4-l...

Development and pharmacological validation of novel methods of B cell activatio…

Shin(John),Spatz(Marianne),Brandish(Philip),… J Pharmacol Toxicol Methods 2016-04-19

...SYK, and PI3Kδ inhibitors were added to rat whole blood prior to activation with dextran-coupled anti-IgD or anti-IgD an...

Borrelia-induced cytokine production is mediated by spleen tyrosine kinase (Syk…

Oosting(Marije),Buffen(Kathrin),Cheng(Shih-C… Cytokine 2016-09-06

...Syk in human cells resulted in lower cytokine production after Borrelia stimulation. In conclusion, Dectin-1 and Dectin-...

The Inhibitory Effects of Low-Dose Ionizing Radiation in IgE-Mediated Allergic …

Joo(Hae Mi),Kang(Su Jin),Nam(Seon Young),Yan… PLoS One 2016-06-09

...Syk, phospholipase Cγ, and protein kinase C, as well as the intracellular free Ca2+ concentration ([Ca2+]i). The phospho...

The TLR4-associated phospholipase D1 activation is crucial for Der f 2-induced …

Choi(H-J),Park(S-Y),Cho(J H),Park(J-W),Sohn(… Allergy 2016-11-09

...Syk, which leads to phosphorylation of PLCγ and membrane translocation of PKCα. p38 MAPK is then activated by PKCα and s...

Membrane-associated glucose-methanol-choline oxidoreductase family enzymes PhcC…

Takahashi(Kenji),Hirose(Yusaku),Kamimura(Nao… Appl Environ Microbiol 2016-08-15

Sphingobium sp. strain SYK-6 is able to degrade various lignin-derived biaryls, including a phenylcoumaran-type compound...

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