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Stability of Syk protein and mRNA in human peripheral blood basophils.

MacGlashan(Donald) J Leukoc Biol 0000-00-00

...Syk expression is 10-fold lower than most other types of leukocytes. There are indirect studies that suggest that Syk pr...

Spleen tyrosine kinase (SYK) is a potential target for the treatment of cutaneo…

Braegelmann(Christine),Hölzel(Michael),Ludbr… Exp Dermatol 0000-00-00

...SYK. SYK-associated genes are strongly upregulated in CLE skin lesions. Importantly, phosphorylated SYK (pSYK) is strong...

Integration of Ligand and Structure Based Approaches for CSAR-2014.

Prathipati(Philip),Mizuguchi(Kenji) J Chem Inf Model 0000-00-00

...SYK), and tRNA (guanine-N(1))-methyltransferase (TrmD). Our docking and scoring workflow incorporates compound clusterin...

A Novel Human Radixin Peptide Inhibits Hepatitis C Virus Infection at the Level…

Bukong(Terence N),Kodys(Karen),Szabo(Gyongyi) Int J Pept Res Ther 0000-00-00

...SYK) as important host therapeutic targets for HCV treatment development. Previously, an ezrin hinge region peptide (Hep...

Roles for the High Affinity IgE Receptor, FcεRI, of Human Basophils in the Path…

Youssef(Lama A),Schuyler(Mark),Wilson(Bridge… Open Allergy J 0000-00-00

...Syk via the ubiquitin/proteasomal pathway is less common in basophils from asthmatic than non-asthmatic donors. The disc...

SYK as a New Therapeutic Target in B-Cell Precursor Acute Lymphoblastic Leukemi…

Uckun(Fatih M),Qazi(Sanjive) J Cancer Ther 0000-00-00

The identification of SYK as a master regulator of apoptosis controlling the activation of the PI3-K/AKT, NFB, and STAT3...

Distinct mechanisms of a phosphotyrosyl peptide binding to two SH2 domains.

Pang(Xiaodong),Zhou(Huan-Xiang) J Theor Comput Chem 0000-00-00

...Syk) is critical for tyrosine phosphorylation of multiple proteins and for regulation of important pathways. Phosphoryla...

Pharmacokinetic-pharmacodynamic modeling of fostamatinib efficacy on ACR20 to s…

Maringwa(John),Kågedal(Matts),Hamrén(Ulrika … J Clin Pharmacol 0000-00-00

...SYK) inhibitor R406, evaluated for the treatment of rheumatoid arthritis (RA). This analysis aimed at developing a pharm...

Proteomic modulation in breast tumors after metformin exposure: results from a …

Kalinsky(K),Zheng(T),Hibshoosh(H),Du(X),Mund… Clin Transl Oncol 0000-00-00

...Syk; and reductions in pMAPK, JNK, Bad, PKC.alpha, and Src. Cyclin D1 change after metformin by IHC was not observed. In...

Suppression of Spleen Tyrosine Kinase (Syk) by Histone Deacetylation Promotes, …

Dasgupta(Nirmalya),Thakur(Bhupesh Kumar),Ta(… J Cell Biochem 0000-00-00

...Syk in colorectal cancers (CRC) is limited, and conflicting reports have been published. We studied Syk expression and i...

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