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Targeting CBLB as a potential therapeutic approach for disseminated candidiasis.

Xiao(Yun),Tang(Juan),Guo(Hui),Zhao(Yixia),Ta… Nat Med 0000-00-00

...SYK, thus inhibiting dectin-1- and dectin-2-mediated innate immune responses. CBLB deficiency or inactivation protects m...

Inhibition of CBLB protects from lethal Candida albicans sepsis.

Wirnsberger(Gerald),Zwolanek(Florian),Asaoka… Nat Med 0000-00-00

...SYK and ubiquitinates SYK, dectin-1, and dectin-2 after fungal recognition. Functionally, CBLB deficiency results in inc...

Methylsulfonylmethane Inhibits RANKL-Induced Osteoclastogenesis in BMMs by Supp…

Joung(Youn Hee),Darvin(Pramod),Kang(Dong You… PLoS One 0000-00-00

...Syk, with a blockade of NF-kB rather than MAPK activity. Furthermore, MSM inhibited RANKL-induced phosphorylation of STA...

Involvement of syk and VEGF-C in invasion of lung adenocarcinoma A549 cells.

Sun(Qifeng),Peng(Chuanliang),Cong(Bo),Hao(Yi… J Cancer Res Ther 0000-00-00

...syk was demonstrated by restriction enzyme electrophoresis and sequencing. RT-PCR revealed Syk expression higher in syk-...

Syk expression in non-small-cell lung cancer and its relation with angiogenesis.

Chuanliang(Peng),Yunpeng(Zhao),Yingtao(Hao),… J Cancer Res Ther 0000-00-00

...Syk) gene in non--small--cell lung cancer and the relationship between Syk mRNA and microvessel density (MVD) in the tum...

Curdlan activates dendritic cells through dectin-1 and toll-like receptor 4 sig…

Kim(Hyung Sook),Park(Ki Hwan),Lee(Hong Kyung… Int Immunopharmacol 0000-00-00

...Syk, Raf-1, Akt, MAPKs, IKK, and NF-κB p65 in DCs. However, curdlan only slightly activated DCs transfected with small i...

FcγRIIB-Independent Mechanisms Controlling Membrane Localization of the Inhibit…

Pauls(Samantha D),Ray(Arnab),Hou(Sen),Vaugha… J Immunol 0000-00-00

...Syk activity is required for optimal stimulation-induced membrane localization of SHIP, whereas neither PI3K or Src kina...

Spleen Tyrosine Kinase: A Crucial Player and Potential Therapeutic Target in Re…

Ma(Terry King-Wing),McAdoo(Stephen P),Tam(Fr… Nephron 0000-00-00

...Syk and potential use of Syk inhibitor in a variety of renal diseases.

Activation of bovine neutrophils by Brucella spp.

Keleher(Lauren L),Skyberg(Jerod A) Vet Immunol Immunopathol 0000-00-00

...SYK kinase blunted the oxidative burst of neutrophils in response to Brucella infection. Interestingly, Brucella spp. di...

E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated …

Zhu(Le-Le),Luo(Tian-Ming),Xu(Xia),Guo(Ya-Hui… J Exp Med 0000-00-00

...Syk-dependent manner. Furthermore, we found that E3 ubiquitin ligase Casitas B-lineage lymphoma protein b (Cbl-b) mediat...

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