Two genes, mutations in which result in the phenotype of tuberous sclerosis (TSC), have recently been cloned. TSC2 on ch...
...TSC2 gene on chromosome 16 encodes a 1784-amino acid putative tumour suppressor protein, tuberin, that functions as a GT...
...TSC2 (16p13), and NF2 (22q12), but no known tumor suppressor gene localizes to 3q27. The mean fractional allelic loss am...
...TSC2) predisposing gene in the Eker rat model. In this study, we searched for mutations of the Tsc2 gene in chemically i...
...Tsc2) heterozygous mutant (Eker) rats in which a germline mutation predisposes the animals to renal cell tumor developme...
...Tsc2 to activate signal transduction and transcription suggests that genes induced by Tsc2 may mediate its biological ro...
...TSC2). Analysis of the 5' flanking region of the hSSTR5 gene has revealed consensus sequences for a number of transcript...
...TSC2-associated loci was observed more frequently in cases with well-differentiated adenocarcinoma (p = 0.086) and assoc...
...Tsc2 gene on mouse Chromosome (Chr) 17, and HUTEX3 was located closely to HSET gene in the HLA class II region of chromo...
...TSC2. Tuberin, the product of TSC2, appears to be localized to the Golgi apparatus and may have a function in vesicular ...
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