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TP53 BRCA1 CRISPR single-cell cancer

Yue(Michael),Pacheco(Gustavo),Cheng(Tao),Li(… Am J Pathol 0000-00-00

...tsc2 and tsc1 genes in the case of LAM. These genes encode the proteins tuberous sclerosis complex (TSC)-1 and TSC2, whi...

Costa(Veronica),Aigner(Stefan),Vukcevic(Mirk… Cell Rep 0000-00-00

...TSC2-deleted pluripotent stem cells. Homozygous TSC2 deletion causes severe developmental abnormalities that recapitulat...

Tripathi(Durga Nand),Zhang(Jiangwei),Jing(Ji… Autophagy 0000-00-00

...TSC2 to suppresses MTORC1 and phosphorylates ULK1 to induce autophagy, and ii) targets specific peroxisomes for pexophag...

Peron(Angela),Vignoli(Aglaia),La Briola(Fran… Am J Med Genet A 0000-00-00

...TSC2 and patients with no mutation identified (P = 0.032). Our study demonstrated that TSC patients do not seem to have ...

Hara(Emilio Satoshi),Ono(Mitsuaki),Yoshioka(… Cells Tissues Organs 0000-00-00

...TSC2 and DDIT4/REDD1. In summary, insulin and TGF-β3 have antagonistic effects when applied concomitantly, with a minima...

Liśkiewicz(Arkadiusz D),Kasprowska(Daniela),… Sci Rep 0000-00-00

...Tsc2+/-) subjected to a ketogenic diet for 4, 6 and 8 months. In spite of existing opinions about the anticancer actions...

Lim(Sun Min),Park(Hyung Soon),Kim(Sangwoo),K… Oncotarget 0000-00-00

...TSC2, NF1, PIK3CA and PIK3CG mutations. Recurrently mutated genes in chromatin remodeling genes (BAP1; n = 2, 12%) and r...

Zhou(Hongyu),Shang(Chaowei),Wang(Min),Shen(T… Biochem Pharmacol 0000-00-00

...TSC2 attenuated CPX inhibition of mTORC1; and CPX also increased AMPK-mediated phosphorylation of raptor (S792). Therefo...

Wang(Hang),Wang(Jianmin),Qu(Hua),Wei(Huili),… Endocrine 0000-00-00

...TSC2/mTOR pathway.

Wang(Y),Hong(X),Wang(J),Yin(Y),Zhang(Y),Zhou… Oncogene 0000-00-00

...TSC2/TBC1D7 protein complex and mTORC1-independent manner, contributing to intrinsic resistance to rapamycin. Rheb-Y35N ...

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