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Polymorphisms in the Pattern Recognition Receptor Mincle Gene (CLEC4E) and Asso…

Bowker(Nicholas),Salie(Muneeb),Schurz(Haiko)… Lung 0000-00-00

...Syk-Card9 signalling pathway in macrophages. Mincle is encoded by CLEC4E, and we investigated polymorphisms in this gene...

FcγR mediates TLR2- and Syk-dependent NLRP3 inflammasome activation by inactiva…

Duffy(Ellen B),Periasamy(Sivakumar),Hunt(Dan… J Leukoc Biol 0000-00-00

...Syk) signaling is required for this NLRP3-dependent IL-1β response, but the alternative IL-1β convertase caspase-8 is in...

Dynamic pre-BCR homodimers fine-tune autonomous survival signals in B cell prec…

Erasmus(M Frank),Matlawska-Wasowska(Ksenia),… Sci Signal 0000-00-00

...Syk. For comparison, we evaluated pre-BCR aggregation mediated by dimeric galectin-1, which has binding sites for carboh...

The Syk-NFAT-IL-2 Pathway in Dendritic Cells Is Required for Optimal Sterile Im…

Khameneh(Hanif Javanmard),Ho(Adrian W S),Spr… J Immunol 0000-00-00

...Syk kinase activation, Ca mobilization, and calcineurin-dependent activation of NFAT, the master transcription factor re...

New emerging therapies in the management of chronic lymphocytic leukemia.

Li(Xiao-Lin),Zhang(Ci-Xian) Oncol Lett 0000-00-00

...SYK/LYN inhibitors, BTK inhibitors, p13k inhibitors and recent developments such as the use of cyclin-dependent kinase i...

PPARγ agonists negatively regulate αIIbβ3 integrin outside-in signalling and pl…

Unsworth(A J),Kriek(N),Bye(A P),Naran(K),Sag… J Thromb Haemost 0000-00-00

...Syk, PLCγ2, FAK and Akt was also observed as a result of reduced interaction of the integrin β3 subunit with Gα13. Studi...

Gene and microRNA modulation upon trabectedin treatment in a human intrahepatic…

Peraldo Neia(Caterina),Cavalloni(Giuliana),C… Oncotarget 0000-00-00

...SYK and LGALS1; their silencing caused a significantly reduction of migration, but did not affect proliferation in in vi...

2-Hydroxy-3-methoxybenzoic acid attenuates mast cell-mediated allergic reaction…

Kim(Yeon-Yong),Je(In-Gyu),Kim(Min Jong),Kang… Acta Pharmacol Sin 0000-00-00

...Syk, Akt, and the nuclear translocation of nuclear factor-κB. In conclusion, o-VA suppresses the mast cell-mediated alle...

IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset an…

Drennan(S),D'Avola(A),Gao(Y),Weigel(C),Chrys… Leukemia 0000-00-00

...SYK-mediated STAT3 activation resulted in suppression of IL10. The data suggest epigenetic control of IL-10 production. ...

Inhibition of BCR signaling using the Syk inhibitor TAK-659 prevents stroma-med…

Purroy(Noelia),Carabia(Júlia),Abrisqueta(Pau… Oncotarget 0000-00-00

...Syk protein, a tyrosine kinase essential for BCR signaling, is therefore a rational candidate for targeted therapy in CL...

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