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Transformation of hamster embryonic fibroblast cells by UV-irradiated human cyt…

Boldogh(I),Gönczöl(E),Váczi(L) Acta Microbiol Acad Sci Hung 1979-10-26

...Tsc2, 87TRH-5-Tsc3) developed from the induced tumour, proved to bear CMV-spcific cytoplasmic and surface antigens. Demo...

Consequences of interrupted Rheb-to-AMPK feedback signaling in tuberous scleros…

Lacher(Markus D),Pincheira(Roxana J),Castro(… Small GTPases 0000-00-00

...TSC2 tumor suppressor complex, which in turn inhibits Rheb, thereby reducing mTORC1 activity and consequently suppressin...

Tnfaip8l1/Oxi-β binds to FBXW5, increasing autophagy through activation of TSC2…

Ha(Ji-Young),Kim(Ji-Soo),Kang(Young-Hee),Bok… J Neurochem 0000-00-00

...TSC2. Thus, Tnfaip8l1/Oxi-β competes with TSC2 to bind FBXW5, increasing TSC2 stability by preventing its ubiquitination...

Conservation of the Tsc/Rheb/TORC1/S6K/S6 Signaling in Fission Yeast.

Nakashima(Akio),Tamanoi(Fuyuhiko) Enzymes 0000-00-00

...Tsc2 complex and Rheb act as upstream players of TORC1 in fission yeast. We have recently demonstrated that TORC1, but n...

The determinants of head and neck cancer: Unmasking the PI3K pathway mutations.

Giudice(Fernanda S),Squarize(Cristiane H) J Carcinog Mutagen 0000-00-00

...TSC2, PTEN, AKT, and mTORC1 and mTORC2 complexes. We discussed how these genetic alterations may affect protein structur...

[Tuberous sclerosis: clinical characteristics and their relationship to genotyp…

Monteiro(T),Garrido(C),Pina(S),Chorão(R),Car… An Pediatr (Barc) 0000-00-00

...TSC2 mutations identified in 58.3% of them. Of the 11 cases of refractory epilepsy, six had the TSC2 gene mutation. In t...

A rapid NGS strategy for comprehensive molecular diagnosis of Birt-Hogg-Dubé sy…

Zhang(Xinxin),Ma(Dehua),Zou(Wei),Ding(Yibing… Respir Res 0000-00-00

...TSC2 genes. For differential diagnosis, these genes should also be screened which makes the diagnostic procedure more ti...

Tuberous sclerosis complex.

Henske(Elizabeth P),Jóźwiak(Sergiusz),Kingsw… Nat Rev Dis Primers 0000-00-00

...TSC2. The disorder can affect both adults and children. First described in depth by Bourneville in 1880, it is now estim...

Tissue kallikrein protects SH-SY5Y neuronal cells against oxygen and glucose de…

Liu(Yanping),Lu(Zhengyu),Cui(Mei),Yang(Qi),T… J Neurochem 0000-00-00

...TSC2/mTOR signaling by AMPK inhibitor compound C and shRNA mediated the knockdown of AMPK α1 and TSC2 but abolished auto...

Women with TSC: Relationship between Clinical, Lung Function and Radiological F…

Di Marco(Fabiano),Terraneo(Silvia),Imeri(Gia… PLoS One 0000-00-00

...TSC2 mutation profile. PFTs, assessed in 64% of women unaffected by cognitive impairments, revealed a lower lung diffusi...

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