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Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of th…

Soucek(T),Pusch(O),Wienecke(R),DeClue(J E),H… J Biol Chem 1997-12-11

...TSC2 antisense oligonucleotides did not undergo G0 arrest after serum withdrawal. Antisense inhibition of TSC2 expressio...

Renal cystic disease in tuberous sclerosis: role of the polycystic kidney disea…

Sampson(J R),Maheshwar(M M),Aspinwall(R),Tho… Am J Hum Genet 1997-11-07

...TSC2 and PKD1, respectively, lie adjacent to each other at chromosome 16p13.3, suggesting a role for PKD1 in the etiolog...

Alterations in the rap1 signaling pathway are common in human gliomas.

Gutmann(D H),Saporito-Irwin(S),DeClue(J E),W… Oncogene 1997-11-12

...TSC2, located on chromosome 16p, and encoding a 180 kDa protein (tuberin) that functions in part as a negative regulator...

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34.

van Slegtenhorst(M),de Hoogt(R),Hermans(C),N… Science 1997-08-26

...TSC2). The TSC1 gene was identified from a 900-kilobase region containing at least 30 genes. The 8.6-kilobase TSC1 trans...

Reduced TSC2 RNA and protein in sporadic astrocytomas and ependymomas.

Wienecke(R),Guha(A),Maize(J C),Heideman(R L)… Ann Neurol 1997-09-05

...TSC2) tumor suppressor gene, has been shown to directly inhibit cell growth and is expressed at high levels in normal ce...

Embryonic neuronal markers in tuberous sclerosis: single-cell molecular patholo…

Crino(P B),Trojanowski(J Q),Dichter(M A),Ebe… Proc Natl Acad Sci U S A 1997-01-16

...TSC2) may disrupt differentiation and maturation of neuronal precursors, since the TSC2 gene product tuberin is believed...

Localization of tuberous sclerosis 2 mRNA and its protein product tuberin in no…

Kerfoot(C),Wienecke(R),Menchine(M),Emelin(J)… Brain Pathol 1997-03-07

...TSC2 on 16p13.3. TSC2 has been cloned, sequenced and encodes a protein (tuberin) which functions as a tumor suppressor. ...

Loss of heterozygosity in tuberous sclerosis hamartomas.

Sepp(T),Yates(J R),Green(A J) J Med Genet 1997-03-13

...TSC2 gene on chromosome 16p13.3 and the TSC1 gene on 9q34. We now describe the spectrum of LOH in 51 TSC hamartomas from...

The tuberin (TSC2), autosomal dominant polycystic kidney disease (PKD1), and so…

Sandford(R),Sgotto(B),Burn(T),Brenner(S) Genomics 1997-03-17

The tuberous sclerosis 2 (TSC2) and polycystic kidney disease 1 (PKD1) genes are adjacent on human chromosome 16p13.3 an...

A novel ribosomal protein L3-like gene (RPL3L) maps to the autosomal dominant p…

Van Raay(T J),Connors(T D),Klinger(K W),Land… Genomics 1997-02-06

...TSC2 genes on chromosome 16p13.3.

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