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Integrated analysis of gene expression and methylation profiles of 48 candidate…

Li(Zibo),Heng(Jianfu),Yan(Jinhua),Guo(Xinwu)… Breast Cancer Res Treat 0000-00-00

...SYK, TGFBR2, TNFRSF10D, WIF1, and WRN) annotated with potential TFBSs in the promoter regions showed negative correlatio...

PPARγ agonists negatively regulate αIIbβ3 integrin outside-in signalling and pl…

Unsworth(A J),Kriek(N),Bye(A P),Naran(K),Sag… J Thromb Haemost 0000-00-00

...Syk, PLCγ2, FAK and Akt was also observed as a result of reduced interaction of the integrin β3 subunit with Gα13. Studi...

Gene and microRNA modulation upon trabectedin treatment in a human intrahepatic…

Peraldo Neia(Caterina),Cavalloni(Giuliana),C… Oncotarget 0000-00-00

...SYK and LGALS1; their silencing caused a significantly reduction of migration, but did not affect proliferation in in vi...

Dynamic pre-BCR homodimers fine-tune autonomous survival signals in B cell prec…

Erasmus(M Frank),Matlawska-Wasowska(Ksenia),… Sci Signal 0000-00-00

...Syk. For comparison, we evaluated pre-BCR aggregation mediated by dimeric galectin-1, which has binding sites for carboh...

Induction of cyclooxygenase-2 gene by Candida albicans through EGFR, ERK, and p…

Wang(Shao-Hung),Wang(Shou-Chieh),Chen(Pei-Ch… Med Mycol 0000-00-00

...Syk inhibitor Syk inhibitor, and epidermal growth factor receptor (EGFR) inhibitor PD168393 to identify which one was th...

The dual Syk/JAK inhibitor cerdulatinib antagonises B-cell receptor and microen…

Blunt(Matthew D),Koehrer(Stefan),Dobson(Rach… Clin Cancer Res 0000-00-00

...Syk/JAK inhibitor currently in clinical trials (NCT01994382), may improve treatment responses in patients.,PBMCs from CL...

Ibrutinib inhibition of Bruton protein-tyrosine kinase (BTK) in the treatment o…

Roskoski(Robert) Pharmacol Res 0000-00-00

...SYK protein kinases following activation of the B cell receptor. BTK in turn catalyzes the phosphorylation and activatio...

Regulation of FcRγ function by site-specific serine phosphorylation.

Shah(Spandan),Gibson(Andrew W),Ji(Chuanyi),D… J Leukoc Biol 0000-00-00

...Syk recruitment and activation. With in vitro kinase assays, PKC-δ and PKA show preferential phosphorylation of S51. Ser...

CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infecti…

Pereira(Milton),Tourlomousis(Panagiotis),Wri… Nat Commun 0000-00-00

...SYK)-mediated NLRP3 activation and repressing inflammasome-associated caspase-8 activity. CARD9 is suppressed during Sal...

Ligand-based and e-pharmacophore modeling, 3D-QSAR and hierarchical virtual scr…

Kaur(Maninder),Silakari(Om) J Biomol Struct Dyn 0000-00-00

...Syk) and janus kinase 3 (JAK3), keys players in immune signaling, by developing ideal pharmacophores integrating Ligand-...

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