We searched for the rat homologue of the human tuberous sclerosis (TSC2) gene mutations in loss of heterozygosity (LOH)-...
...Tsc2/TSC2 is conserved between the two species. Characterization of the 5' region of Tsc2 and TSC2 will facilitate studi...
...TSC2) tumor suppressor gene, has been shown to directly inhibit cell growth and is expressed at high levels in normal ce...
...TSC2). The TSC1 gene was identified from a 900-kilobase region containing at least 30 genes. The 8.6-kilobase TSC1 trans...
...TSC2, a cytosolic factor, rabaptin-5, was found to associate with a distinct domain lying adjacent to the TSC2 GAP homol...
...TSC2 gene on 16p13.3. This implies that these lesions are clonal. We have studied X-chromosome inactivation, as a marker...
...TSC2 gene, which have severe infantile polycystic kidney disease, have also been characterised. The full length transcri...
...TSC2 in the adult brain and developing central nervous system. Abundant TSC2 expression was detected in the adult cerebe...
...TSC2) gives rise to dominantly inherited cancer in the Eker rat model, as well as a tumor suppressor nature for the Tsc2...
...TSC2 contiguous-gene syndrome, and the likely mutational mechanism in PKD1 is considered.
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