...TSC2 gene product, tuberin, we have designed an RT-PCR-based assay system to scan the expressed coding region of the TSC...
...TSC2) and seven tumor suppressor gene-containing regions (TP53, NF1, NF2, BRCA1, APC, VHL, and MLM) in 20 hamartomas fro...
...TSC2, on chromosome 16p13.3. Clinical criteria for diagnosis have been established, but diagnosis of patients with minim...
...TSC2) disease genes. An estimated 20 genes are present in this region of chromosome 16. We have initiated studies to ide...
...TSC2, has recently been cloned. In this report, the murine TSC2 homologue was cloned and characterized. cDNA clones enco...
Germ-line mutations of the TSC2 tumour suppressor gene have been identified in humans with tuberous sclerosis and in the...
...TSC2 tumors are more likely than TSC1 tumors to require surgical resection or that TSC2 is more common than TSC1 in our ...
...Tsc2. Tumor cells expressing the transfected Tsc2 gene became more anchorage-dependent and lost their ability to form tu...
...TSC2). Another one that was discovered earlier in chromosome 9 (TSC1) has not yet been characterized. The gene product f...
...TSC2) genes, who have tuberous sclerosis and severe childhood-onset polycystic kidney disease, have also been described....
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