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PI3K/Akt promotes feedforward mTORC2 activation through IKKα.

Dan(Han C),Antonia(Ricardo J),Baldwin(Albert… Oncotarget 0000-00-00

...TSC2 and PRAS40, indicating the existence of multiple mechanisms of Akt activation in cells. In addition, loss of IKKα s...

The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy v…

Bento(Carla F),Ashkenazi(Avraham),Jimenez-Sa… Nat Commun 0000-00-00

...TSC2, which leads to mTORC1 activation and decreased TFEB-mediated transcription of SYT11, while increased protein turno...

mTOR inhibitor reverses autistic-like social deficit behaviours in adult rats w…

Schneider(Miriam),de Vries(Petrus J),Schönig… Eur Arch Psychiatry Clin Neur… 0000-00-00

...Tsc2 (Eker)-rats express social deficits similar to Tsc2 mice, with additive social deficits from developmental status...

Isolation of individual cellular components from lung tissues of patients with …

Ando(Katsutoshi),Fujino(Naoya),Mitani(Keiko)… Am J Physiol Lung Cell Mol Ph… 0000-00-00

...TSC2 LOH. These isolated cells were viable and subsequently amenable to cell culture. This method enables us to isolate ...

Women with TSC: Relationship between Clinical, Lung Function and Radiological F…

Di Marco(Fabiano),Terraneo(Silvia),Imeri(Gia… PLoS One 0000-00-00

...TSC2 mutation profile. PFTs, assessed in 64% of women unaffected by cognitive impairments, revealed a lower lung diffusi...

Genomic profiling of malignant phyllodes tumors reveals aberrations in FGFR1 an…

Liu(Su-Yang),Joseph(Nancy M),Ravindranathan(… Mod Pathol 0000-00-00

...TSC2 mutation, EGFR amplification and PTEN loss. Seven (70%) malignant phyllodes tumors harbored TERT aberrations (six p...

Tuberous sclerosis complex.

Henske(Elizabeth P),Jóźwiak(Sergiusz),Kingsw… Nat Rev Dis Primers 0000-00-00

...TSC2. The disorder can affect both adults and children. First described in depth by Bourneville in 1880, it is now estim...

Tissue kallikrein protects SH-SY5Y neuronal cells against oxygen and glucose de…

Liu(Yanping),Lu(Zhengyu),Cui(Mei),Yang(Qi),T… J Neurochem 0000-00-00

...TSC2/mTOR signaling by AMPK inhibitor compound C and shRNA mediated the knockdown of AMPK α1 and TSC2 but abolished auto...

A rapid NGS strategy for comprehensive molecular diagnosis of Birt-Hogg-Dubé sy…

Zhang(Xinxin),Ma(Dehua),Zou(Wei),Ding(Yibing… Respir Res 0000-00-00

...TSC2 genes. For differential diagnosis, these genes should also be screened which makes the diagnostic procedure more ti...

Elevation of Ser9 phosphorylation of GSK3β is required for HERV-W env-mediated …

Qin(Chengchen),Li(Shan),Yan(Qiujin),Wang(Xiu… Neurosci Lett 0000-00-00

...TSC2 mRNAs were upregulated (p<0.05). These data suggested that overexpression of HERV-W env might activate the GSK3β si...

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