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Elevation of Ser9 phosphorylation of GSK3β is required for HERV-W env-mediated …

Qin(Chengchen),Li(Shan),Yan(Qiujin),Wang(Xiu… Neurosci Lett 0000-00-00

...TSC2 mRNAs were upregulated (p<0.05). These data suggested that overexpression of HERV-W env might activate the GSK3β si...

[Diagnosis of tuberous sclerosis complex focusing on prenatal period].

Filipová(H),Procházka(M),Vrtěl(R) Ceska Gynekol 0000-00-00

...TSC2. Complex formed by the products of the TSC genes regulates cell growth and proliferation by inhibition of mTORC1 si...

Oncogenic effects of urotensin-II in cells lacking tuberous sclerosis complex-2.

Goldberg(Alexander A),Joung(Kwang-Bo),Mansur… Oncotarget 0000-00-00

...TSC2. Urotensin-II increased cell viability and proliferation in TSC2-deficient cells, but not in TSC2-reconstituted cel...

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resi…

Castel(Pau),Ellis(Haley),Bago(Ruzica),Toska(… Cancer Cell 0000-00-00

...TSC2. Targeting either PDK1 or SGK1 prevents mTORC1 activation, restoring the antitumoral effects of PI3Kα inhibition in...

Activation of the ER stress and calcium signaling in angiomyolipoma.

Novotna(B),Takacova(M),Hudecova(S),Lencesova… Neoplasma 0000-00-00

...TSC2 expression, hypoxic status, expression of endoplasmic reticulum (ER) stress markers and calcium transport from the ...

VPS34 regulates TSC1/TSC2 heterodimer to mediate RheB and mTORC1/S6K1 activatio…

Mohan(Nishant),Shen(Yi),Dokmanovic(Milos),En… Oncotarget 0000-00-00

...TSC2 from the TSC1/TSC2 heterodimer, leading to TSC2 ubiquitination and degradation. Downregulation of TSC2 promotes the...

The impact of mosaicism in preimplantation genetic diagnosis (PGD): approaches …

Naja(Roy Pascal),Dhanjal(Seema),Doshi(Alpesh… Prenat Diagn 0000-00-00

...TSC2).,PGD protocol development was carried out using single cells from the patients. PGD was carried out on polar bodie...

Chronic Stress Aggravates Cognitive Impairment and Suppresses Insulin Associate…

Han(Bing),Yu(Lulu),Geng(Yuan),Shen(Li),Wang(… J Alzheimers Dis 0000-00-00

...TSC2 phosphorylation. Furthermore, insulin and Akt/mTOR signaling pathways were further decreased in APP/PS1 mice after ...

Focal Adhesion Kinase Directly Interacts with TSC2 Through Its FAT Domain and R…

Zheng(Xu),Bao(Wenlei),Yang(Jiaofu),Zhang(Tao… DNA Cell Biol 0000-00-00

...TSC2 (Tuberous sclerosis 2) tuberin domain through its C-terminus, which contains the complete FAT domain. In conclusion...

[Clinical application value of echocardiography combined with genetic testing i…

Liu(X W),Gu(X Y),Hao(X Y),Shang(J F),Han(L),… Zhonghua Fu Chan Ke Za Zhi 0000-00-00

...TSC2 gene mutation and the other 1 case was with TSC1 gene mutation. The family gene was investigated in the 5 cases, wh...

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