...TSC2, which leads to mTORC1 activation and decreased TFEB-mediated transcription of SYT11, while increased protein turno...
...Tsc2 (Eker)-rats express social deficits similar to Tsc2 mice, with additive social deficits from developmental status...
...TSC2, and MAPK pathway genes (BRAF, KRAS, and NRAS) also identified. Mutations in consensus cancer genes (category III) ...
...TSC2, leading to mammalian target of rapamycin hyperactivation. Patients with TSC develop hamartomas in brain, lungs, li...
...TSC2 were more common in responders, 12 (28%) of 43, than nonresponders, 4 (11%) of 36 (P = 0.06). Mutations in TSC1 or ...
...TSC2. The increase in REDD1 abundance was rapidly reversed upon iron repletion of cells but was also attenuated by inhib...
...Tsc2 results in excess cell growth that eventually forms hamartoma in multiple organs. Our study using a mouse model wit...
...TSC2 mutations account for the majority of tuberous sclerosis complex cases. The TSC1 and TSC2 proteins assemble into a ...
...TSC2(Thr1462) , AMPK(Thr172) and REDD1 protein were greater for 1 compared with 5 min inter-set rest. Serum testosterone...
...Tsc2 were assayed by immunohistochemistry (N=125). Genomic DNA sequencing was conducted on a panel of 287 cancer-related...
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