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Variants Within TSC2 Exons 25 and 31 Are Very Unlikely to Cause Clinically Diag…

Ekong(Rosemary),Nellist(Mark),Hoogeveen-West… Hum Mutat 0000-00-00

...TSC2 exons, and TSC2 expression data demonstrates that the majority of TSC2 transcripts lack exons 25 and/or 31 in many ...

Focal adhesion kinase signaling is decreased 56 days following spinal cord inju…

Graham(Z A),Qin(W),Harlow(L C),Ross(N H),Bau… Spinal Cord 0000-00-00

...TSC2 or total p70S6k. SCI resulted in a greater expression of total Akt. mRNA expression of FAK and the α7 or β1 integri...

Role of mTOR signaling pathway in the pathogenesis of subependymal giant cell a…

Kumari(Kalpana),Sharma(Mehar C),Kakkar(Aanch… Neurol India 0000-00-00

...TSC2 genes are linked to the mammalian target of rapamycin (mTOR) cell signaling pathway. We aimed to analyze TSC1 and T...

Renal angiomyolipoma bleeding in a patient with TSC2/PKD1 contiguous gene syndr…

Furlano(Mónica),Barreiro(Yaima),Martí(Teresa… Nefrologia 0000-00-00

...TSC2/PKD1 contiguous gene syndrome, presenting with tuberous sclerosis (TS) and autosomal dominant polycystic kidney dis...

Applying the Lessons of Tuberous Sclerosis: The 2015 Hower Award Lecture.

Roach(E Steve) Pediatr Neurol 0000-00-00

...TSC2 can cause tuberous sclerosis complex. Their two gene products, hamartin and tuberin, form a physical complex which ...

The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanic…

Kathage(Barbara),Gehlert(Sebastian),Ulbricht… Biochim Biophys Acta 0000-00-00

...TSC2. Interaction with BAG3 results in a recruitment of TSC complexes to actin stress fibers, where the complexes act on...

TSC2 Deficiency Unmasks a Novel Necrosis Pathway That Is Suppressed by the RIP1…

Filipczak(Piotr T),Thomas(Cindy),Chen(Wenshu… Cancer Res 0000-00-00

...TSC2 complex, resulting in the hyperactivation of mTOR- and Raf/MEK/MAPK-dependent signaling that stimulates tumor cell ...

Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions…

Ren(Siying),Luo(Yongfeng),Chen(Hui),Warburto… Am J Pathol 0000-00-00

...Tsc2 in mesoderm-derived cells causes epithelial-lined renal cysts. Therefore, Tsc2-mTOR signaling in mesenchyme is esse...

Benign clear cell "sugar" tumor of the lung in a patient with Birt-Hogg-Dubé sy…

Gunji-Niitsu(Yoko),Kumasaka(Toshio),Kitamura… BMC Med Genet 0000-00-00

...TSC2) gene.,In a 38-year-old Asian woman, two well-circumscribed nodules in the left lung and multiple thin-walled, irre...

Somatic overgrowth disorders of the PI3K/AKT/mTOR pathway & therapeutic strateg…

Keppler-Noreuil(Kim M),Parker(Victoria E R),… Am J Med Genet C Semin Med Ge… 0000-00-00

...TSC2 and germline loss-of function mutations of these genes are established to cause PTEN Hamartoma Tumor Syndrome and T...

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