...TSC2 genes producing constitutive activation of the mammalian target of rapamycin (mTOR) pathway presents an opportunity...
...TSC2/Tsc2 gene (tuberin) together with hamartin, the product of another TSC gene (TSC1/Tsc1), suppresses mammalian/mecha...
...TSC2)-Ras homolog enriched in brain (Rheb) axis. Moreover, since initiation of translation is reliant on mRNA, it is als...
...TSC2 protein expression, and 1 culture showed biallelic mutation in TSC2, one of which was germline and the second acqui...
...TSC2-deficient cells. Importantly, molecular depletion of Bim by siRNA in Tsc2-deficient cells increased lung colonizati...
...TSC2 in Caki-2 cells had similar results to 786-O cells, and mTOR silencing in 786-O cells rescued the inhibitory effect...
...TSC2, FOXO, and 14-3-3 expression in uterine leiomyoma cells. . In the concentrations of 10%30%, GZFLC drug serum could ...
...TSC2 pathway that was associated with reduced mTOR S2448 and ULK-1 S757 phosphorylation and increased ULK-1 S317 and ATG...
...TSC2. We sought to generate a mouse model of one or more of these tumor types by targeting deletion of the Tsc1 gene to ...
...TSC2 and KCNQ2) and achieved up to 85% efficiency of gene targeting in the differentiated cells. In particular, we devis...
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