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Bay 61-3606 Sensitizes TRAIL-Induced Apoptosis by Downregulating Mcl-1 in Breas…

Kim(So-Young),Park(Sang Eun),Shim(Sang-Mi),P… PLoS One 2016-06-28

...Syk) inhibitor Bay 61-3606 was identified as a TRAIL sensitizer. Amplification of TRAIL-induced apoptosis by Bay 61-3606...

[The importance of B cell-T cell interaction in autoimmune diseases].

Iwata(Shigeru),Tanaka(Yoshiya) Nihon Rinsho Meneki Gakkai Ka… 2016-09-01

...Syk/Btk/JAK caused robust gene expression of AICDA, BCL6, XBP1 and IgG production. We found that levels of Syk/Btk phosp...

Substrate Distortion and the Catalytic Reaction Mechanism of 5-Carboxyvanillate…

Vladimirova(Anna),Patskovsky(Yury),Fedorov(A… J Am Chem Soc 2016-10-24

...SYK-6 (kcat = 2.2 s(-1) and kcat/Km = 4.0 × 10(4) M(-1) s(-1)) and Novosphingobium aromaticivorans (kcat = 27 s(-1) and ...

ASK1/JNK-mediated TAp63 activation controls the cell survival signal of baicale…

Park(Ga Bin),Kim(Yeong Seok),Lee(Hyun-Kyung)… Mol Cell Biochem 2016-10-31

...Syk/Src-mediated PI3K/Akt activation, in baicalein-treated EBV-transformed B cells. Meanwhile, ASK1/JNK-dependent TAp63 ...

Inhibitory effect of fermented Arctium lappa fruit extract on the IgE-mediated …

Yoo(Jae-Myung),Yang(Ju Hye),Yang(Hye Jin),Ch… Int J Mol Med 2016-10-27

...Syk, which are involved in the FcεRI signaling pathway, that of phosphoinositide phospholipase C (PLC)γ1/2 and protein k...

Ethanol Inhibits High-Affinity Immunoglobulin E Receptor (FcεRI) Signaling in M…

Draberova(Lubica),Paulenda(Tomas),Halova(Iva… PLoS One 2016-06-27

...SYK kinases, LAT adaptor protein, phospholipase Cγ, STAT5, and AKT and internalization of aggregated FcεRI. Interestingl...

Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives …

Yeomans(Alison),Thirdborough(Stephen M),Vall… Blood 2016-06-14

...SYK (tamatinib). Anti-IgM-induced mRNA translation was associated with increased expression of translation initiation fa...

Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B…

Goldstein(Rebecca L),Yang(Shao Ning),Taldone… J Clin Invest 2016-02-04

...SYK and BTK. Consequently, treatment of BCR-dependent ABC DLBCL cells with PU-H71 attenuated BCR signaling, calcium flux...

Emerging roles of podoplanin in vascular development and homeostasis.

Pan(Yanfang),Xia(Lijun) Front Med 2016-09-23

...Syk kinase. This mechanism is required to initiate and maintain separation of blood and lymphatic vessels and to stabili...

β-Glucan-Activated Human B Lymphocytes Participate in Innate Immune Responses b…

Ali(Mohamed F),Driscoll(Christopher B),Walte… J Immunol 2016-03-15

...SYK, MAPKs, and the transcription factors NF-κB and AP-1. Moreover, we observed that conditioned media from β-glucan-sti...

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