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Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires I…

Zhi(Huiying),Dai(Jing),Liu(Junling),Zhu(Jieq… PLoS One 2016-05-10

...Syk were found to play key roles in IgG-induced platelet activation events. Taken together, our data suggest a complex f...

Increased SYK activity is associated with unfavorable outcome among patients wi…

Boros(Katalin),Puissant(Alexandre),Back(Morg… Oncotarget 2016-07-25

...SYK activation in primary patient samples have been lacking. In this study we quantified phosphorylated SYK (P-SYK) in A...

Spleen Tyrosine Kinase Modulates Fibrous Airway Obliteration and Associated Lym…

Matsuda(Y),Wang(X),Oishi(H),Guan(Z),Saito(M)… Am J Transplant 2016-10-25

...Syk in development of OB, using an intrapulmonary tracheal transplant model of OB with the conditional Syk-knockout Syk(...

Epstein-Barr virus Latent Membrane Protein 2A (LMP2A)-mediated changes in Fas e…

Incrocci(Ryan),Hussain(Samira),Stone(Amanda)… Cell Immunol 2016-04-18

...Syk-dependent increase in sensitivity to Fas-mediated apoptosis, due to an LMP2A-dependent enhancement in Fas expression...

Myeloid cell-mediated renal injury in rapidly progressive glomerulonephritis de…

Ryan(Jessica),Ma(Frank Y),Han(Yingjie),Ozols… J Pathol 2016-05-23

...Syk gene deletion in myeloid cells (Syk(My) ) versus Syk(f/f) littermate controls in nephrotoxic serum nephritis - a mod...

BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only p…

Carter(M J),Cox(K L),Blakemore(S J),Bogdanov… Cell Death Differ 2016-10-14

...Syk or MEK. These observations indicate that BCR signaling elicits maximal cell death through upregulation of multiple B...

Lectin binding to surface Ig variable regions provides a universal persistent a…

Linley(Adam),Krysov(Sergey),Ponzoni(Maurilio… Blood 2016-01-14

...SYK inhibitor (tamatinib) or the BTK inhibitor (ibrutinib) each blocked phosphorylation. Activation by DC-SIGN occurred ...

Anchor-based classification and type-C inhibitors for tyrosine kinases.

Hsu(Kai-Cheng),Sung(Tzu-Ying),Lin(Chih-Ta),C… Sci Rep 2016-05-13

...SYK) and 14% of 64 kinases, respectively. According to the guide of our anchor model, we synthesized three RA derivative...

Liposomal Nanoparticles of a Spleen Tyrosine Kinase P-Site Inhibitor Amplify th…

Uckun(Fatih M),Myers(Dorothea E),Cheng(Jianj… EBioMedicine 2016-08-15

...SYK-P-site inhibitor C61 ("C61-LNP"). C61-LNP plus low dose total body irradiation (TBI) was substantially more effectiv...

Spiraeoside inhibits mast cells activation and IgE-mediated allergic responses …

Kim(Jung Kuk),Seo(Young-Kyo),Park(Sehoon),Pa… Biochem Cell Biol 2016-02-22

...Syk), linker for activation of T cells (LAT), and downstream MAPKs, such as ERK1/2, p38, and JNK, eventually attenuating...

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