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Interleukin-10-producing CD5+ B cells inhibit mast cells during immunoglobulin …

Kim(Hyuk Soon),Kim(A-Ram),Kim(Do Kyun),Kim(H… Sci Signal 2016-02-04

...Syk in mast cells. Together, these findings suggest that an important function of IL-10-producing CD5(+) B cells is inhi...

Introduction of chemically labile substructures into Arabidopsis lignin through…

Tsuji(Yukiko),Vanholme(Ruben),Tobimatsu(Yuki… Plant Biotechnol J 2016-04-05

...SYK-6 possesses a Cα-dehydrogenase (LigD) enzyme that has been shown to oxidize the α-hydroxy functionalities in β-O-4-l...

Development and pharmacological validation of novel methods of B cell activatio…

Shin(John),Spatz(Marianne),Brandish(Philip),… J Pharmacol Toxicol Methods 2016-04-19

...SYK, and PI3Kδ inhibitors were added to rat whole blood prior to activation with dextran-coupled anti-IgD or anti-IgD an...

RAC1 P29S regulates PD-L1 expression in melanoma.

Vu(Ha Linh),Rosenbaum(Sheera),Purwin(Timothy… Pigment Cell Melanoma Res 2016-06-22

...Syk as being selectively upregulated with RAC1 P29S expression and downregulated with RAC1 P29S depletion. Using the mel...

Progress in Small Molecule Therapeutics for the Treatment of Retinoblastoma.

Pritchard(Eleanor M),Dyer(Michael A),Guy(R K… Mini Rev Med Chem 2016-11-01

...SYK) inhibitors.

Syk-mediated tyrosine phosphorylation of mule promotes TNF-induced JNK activati…

Lee(C K),Yang(Y),Chen(C),Liu(J) Oncogene 2016-09-01

...Syk) prevents its dissociation from ARF, thereby inhibiting Mule E3 ligase activity and TNF-induced JNK activation and c...

SYK expression endows human ZAP70-deficient CD8 T cells with residual TCR signa…

Hauck(Fabian),Blumenthal(Britta),Fuchs(Sebas… Clin Immunol 2016-02-29

...SYK that correlated with residual TCR signaling including calcium flux and degranulation. Our findings highlight the dif...

Structural Basis of Stereospecificity in the Bacterial Enzymatic Cleavage of β-…

Helmich(Kate E),Pereira(Jose Henrique),Gall(… J Biol Chem 2016-08-09

...SYK-6. Here, we present x-ray crystal structures and biochemical characterization of the glutathione-dependent β-etheras...

TSLP production by dendritic cells is modulated by IL-1β and components of the …

Elder(Matthew J),Webster(Steven J),Williams(… Eur J Immunol 2016-06-30

...Syk, NF-κB, and p38 MAPK signaling. In addition, TSLP production by mDCs is greatly enhanced by IL-1β, but not TNF-α, in...

Dietary Compound Kaempferol Inhibits Airway Thickening Induced by Allergic Reac…

Shin(Daekeun),Park(Sin-Hye),Choi(Yean-Jung),… Int J Mol Sci 2016-10-05

...Syk-phospholipase Cγ (PLCγ) pathway was dampened in kaempferol-supplemented mast cells. These results demonstrated that ...

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